Department of Chemistry, Government College University Faisalabad, Faisalabad, Pakistan.
Pak J Pharm Sci. 2021 Sep;34(5(Supplementary)):1885-1890.
The facile and efficient protocol for the synthesis of N-phenyl piperazine based di-thio-carbamates has been reported under neat conditions. A library of novel piperazine based di-thio-carbamates (3a-h) in excellent yields has been prepared. Solvent free, catalyst free and easy work up conditions make this protocol an attractive synthetic protocol to achieve novel biologically active di-thio-carbamates. The synthesized molecules have been characterized by FT-IR, HNMR and CNMR spectroscopic techniques. The pharmacological aspects of these derivatives have been evaluated via hemolysis and thrombolysis. All the target molecules (3a-h) exhibit mild to medium potential as hemolytic and thrombolytic agents. Among the synthesized derivatives, compound 3c showed least cytotoxicity and better thrombolytic potential.
已报道了在无溶剂条件下简便高效合成基于 N-苯基哌嗪的二硫代氨基甲酸盐的方法。以优异的产率制备了基于哌嗪的新型二硫代氨基甲酸盐（3a-h）库。无溶剂、无催化剂和易于处理的条件使该方法成为获得新型生物活性二硫代氨基甲酸盐的有吸引力的合成方法。合成的分子已通过傅里叶变换红外光谱（FT-IR）、氢核磁共振（HNMR）和碳核磁共振（CNMR）光谱技术进行了表征。通过溶血和溶栓评估了这些衍生物的药理学特性。所有目标分子（3a-h）均表现出作为溶血和溶栓剂的温和至中等潜力。在所合成的衍生物中，化合物 3c 表现出最低的细胞毒性和更好的溶栓潜力。
