Npr2 突变小鼠的肠系膜显示出血管舒张和未发育的脂肪细胞。
Npr2 mutant mice show vasodilation and undeveloped adipocytes in mesentery.
机构信息
Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan.
Laboratory of Pathology and Development, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan.
出版信息
BMC Res Notes. 2021 Nov 27;14(1):438. doi: 10.1186/s13104-021-05853-9.
OBJECTIVE
The biological importance for the signaling of C-type natriuretic peptide (CNP) and natriuretic peptide receptor B (NPR-B) has been recognized. However, the details remain unclear and are debatable. The Npr2 is a gene of NPR-B, and we previously reported a unique phenotype of a spontaneous mutant mouse lacking Npr2 (Npr2), such as severe ileus-like disorder with bloodless blood vessels. In this study, we analyzed the bloodless mesenteric vascular morphology of Npr2 by histological observation to clarify the effects of the CNP/NPR-B signal deficiency.
RESULTS
Blood vessels in the mesentery were clearly dilated in the preweaning Npr2 mice. Additionally, in the Npr2 mice, the lacteals were partially dilation or randomly direction mucosal epithelial cells in villi, and mesenteric adipocytes were undeveloped. These findings provide important information for understanding the role of CNP/NPR-B signals on intestine with mesentery.
目的
C 型利钠肽（CNP）和利钠肽受体 B（NPR-B）信号的生物学重要性已得到认可。然而，其细节仍不清楚，存在争议。Npr2 是 NPR-B 的一个基因，我们之前报道了一种缺乏 Npr2（Npr2）的自发性突变小鼠的独特表型，如严重的类似肠梗阻的疾病伴有无血色的血管。在这项研究中，我们通过组织学观察分析了 NPR-B 的无血色肠系膜血管形态，以阐明 CNP/NPR-B 信号缺乏的影响。
结果
新生 Npr2 小鼠的肠系膜血管明显扩张。此外，在 Npr2 小鼠中，乳糜管部分扩张或绒毛中黏膜上皮细胞呈随机方向排列，肠系膜脂肪细胞发育不良。这些发现为理解 CNP/NPR-B 信号在肠系膜肠中的作用提供了重要信息。
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