Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea; Center for Synaptic Brain Dysfunction, Institute for Basic Science, Daejeon, South Korea; Mental Health Research Institute, National Center for Mental Health, Seoul, South Korea.
Department of Anatomy, College of Medicine, Korea University, Seoul, South Korea.
Biochem Biophys Res Commun. 2022 Jan 1;586:114-120. doi: 10.1016/j.bbrc.2021.11.049. Epub 2021 Nov 20.
Prepulse inhibition (PPI) is a neurophysiological finding that is decreased in schizophrenia patients and has been used in pathophysiology studies of schizophrenia and the development of antipsychotic drugs. PPI is affected by several drugs including amphetamine, ketamine, and nicotinic agents, and it is reported that several brain regions and modulatory neurotransmitters are involved in PPI. Here we showed that mice with IRSp53 deletion in each dopaminergic, cholinergic, oxytocinergic, and serotoninergic modulatory neurons showed a decrease in PPI. Other than PPI, there were no other behavioral changes among IRSp53 deletion mice. Through this study, we could reconfirm that dysfunction of each modulatory neuron such as dopamine, acetylcholine, oxytocin, and serotonin can result in PPI impairment, and it should be considered that PPI could be broadly affected by changes in one of a certain kind of modulatory neurons.
前脉冲抑制（PPI）是一种神经生理学发现，在精神分裂症患者中降低，并已用于精神分裂症的病理生理学研究和抗精神病药物的开发。PPI 受几种药物的影响，包括安非他命、氯胺酮和烟碱类药物，据报道，几个脑区和调节性神经递质参与了 PPI。在这里，我们发现每个多巴胺能、胆碱能、催产素能和血清素能调节神经元中 IRSp53 缺失的小鼠的 PPI 减少。除了 PPI，IRSp53 缺失的小鼠没有其他行为变化。通过这项研究，我们可以再次确认，多巴胺、乙酰胆碱、催产素和血清素等每种调节神经元的功能障碍都会导致 PPI 受损，应该考虑到 PPI 可能会受到某种调节神经元变化的广泛影响。
