Department of Neurology, The First Hospital of Jilin University, Changchun, China.
Department of Hepatology, Second People's Clinical Colleague of Tianjin Medical University, Tianjin, China.
Epilepsy Behav. 2021 Dec;125:108448. doi: 10.1016/j.yebeh.2021.108448. Epub 2021 Nov 25.
To determine whether and the extent to which depression severity mediates the impact of perceived stigma on quality of life in patients with epilepsy (PWE).
A consecutive cohort of 165 PWE was invited to participate in this study. Each participant completed the Kilifi Stigma Scale of Epilepsy (KSSE), Depression Inventory for Epilepsy (NDDI-E), and Quality of Life in Epilepsy Inventory (QOLIE-31). Mediation analysis was employed to assess whether depression severity mediates the relationship between perceived stigma and quality of life.
Perceived stigma was positively associated with depression severity and negatively associated with quality of life in PWE. The mediation analysis confirmed that perceived stigma had an indirect effect on the quality of life through the mediating variable of depression severity in PWE (B = -0.576, SE = 0.097, Bootstrap95% CI = -0.784 to -0.405). The indirect effects of perceived stigma on quality of life through depression severity accounted for 57.7% of the total effects of perceived stigma on quality of life.
This study provided evidence that depression severity mediates the impact that perceived stigma has on quality of life, indicating that assessment of and interventions targeting depression may be appropriate for PWE.
确定抑郁严重程度是否以及在何种程度上中介了感知耻辱对癫痫患者（PWE）生活质量的影响。
连续招募了 165 名 PWE 参与本研究。每位参与者都完成了基利夫癫痫耻辱量表（KSSE）、癫痫抑郁量表（NDDI-E）和癫痫生活质量量表（QOLIE-31）。采用中介分析评估抑郁严重程度是否在感知耻辱与生活质量之间的关系中起中介作用。
感知耻辱与 PWE 的抑郁严重程度呈正相关，与生活质量呈负相关。中介分析证实，感知耻辱通过抑郁严重程度这一中介变量对 PWE 的生活质量有间接影响（B= -0.576，SE= 0.097，Bootstrap95%CI= -0.784 至 -0.405）。感知耻辱通过抑郁严重程度对生活质量的间接影响占感知耻辱对生活质量总影响的 57.7%。
本研究提供了证据表明，抑郁严重程度中介了感知耻辱对生活质量的影响，这表明评估和针对抑郁的干预措施可能对 PWE 是合适的。
