Tran Kiem Hao, Nguyen-Thi Kim Hoa, Pham Nguyen Cuong, Dang Cong Thuan
Department of Health, Provincial People's Committee, Hue city, 530000, Viet Nam.
Pediatric Center, Hue Central Hospital, Hue city, 530000, Viet Nam.
Radiol Case Rep. 2021 Nov 18;17(1):245-249. doi: 10.1016/j.radcr.2021.10.044. eCollection 2022 Jan.
Loffler syndrome is an uncommon, self-limited, benign pulmonary eosinophilia that usually lasts less than a month. Abnormal chest radiography occurs in 95% of patients; however, computed tomography findings are not well described. We present clinical features, radiological, and pathological findings of Loeffler's syndrome with secondary bacterial pneumonia in a child. He presented with dry cough, hemoptysis 2 times, chest pain for 1 week. Blood tests revealed high C-reactive protein levels and eosinophilia. On the initial computed tomography (CT) scan, a lesion was discovered at the upper edge of the right lung hilum. The lesion developed in size, together with right pleural effusion, on the repeated CT scan. A lung biopsy revealed a substantial number of inflammatory cells, including eosinophils and neutrophils. After ruling all other possibilities, Loffler's syndrome was confirmed. As a result of antibiotic treatment, favorable outcomes were confirmed by improving clinical symptoms and follow-up chest CT scans. A close combination of pulmonary symptoms, peripheral blood eosinophilia, abnormal chest imaging, and histopathological findings must be taken to confirm the diagnosis of Loeffler's syndrome.
吕弗勒综合征是一种罕见的、自限性的良性肺嗜酸性粒细胞增多症，通常持续时间少于一个月。95%的患者胸部X线检查异常；然而，计算机断层扫描结果描述并不充分。我们报告了一名儿童吕弗勒综合征合并继发性细菌性肺炎的临床特征、影像学及病理结果。他表现为干咳、咯血2次、胸痛1周。血液检查显示C反应蛋白水平升高和嗜酸性粒细胞增多。在初次计算机断层扫描（CT）时，在右肺门上部边缘发现一个病灶。在重复CT扫描时，病灶增大，并伴有右侧胸腔积液。肺活检显示大量炎症细胞，包括嗜酸性粒细胞和中性粒细胞。排除所有其他可能性后，确诊为吕弗勒综合征。经过抗生素治疗，临床症状改善及胸部CT随访扫描证实预后良好。必须综合肺部症状、外周血嗜酸性粒细胞增多、胸部影像学异常及组织病理学结果来确诊吕弗勒综合征。
