Shakoei Safoura, Nakhjavani Manouchehr, Mirmiranpoor Hossein, Motlagh Mohana Alinejad, Azizpour Arghavan, Abedini Robabeh
Drs. Shakoei and Motlagh are with the Department of Dermatology at Imam Khomeini Hospital, Tehran University of Medical Sciences in Tehran, Iran.
Drs. Nakhjavani and Mirmiranpoor are with the Endocrinology and Metabolism Research Center at Vali-Asr Hospital, Tehran University of Medical Sciences in Tehran, Iran.
J Clin Aesthet Dermatol. 2021 Jul;14(7):38-41. Epub 2021 Jul 1.
soriasis is a chronic, immune-mediated, inflammatory disease. Previous studies have indicated a possible role of oxidative stress in the pathogenesis of psoriasis.
We sought to compare special oxidative stress and antioxidant markers in psoriatic patients.
This study included 35 patients with psoriasis and 35 healthy controls. Serum levels of oxidant markers, including advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs), as well as antioxidant enzymes, including lecithin-cholesterol acyltransferase (LCAT), paraoxonase-1 (PON1), and ferric-reducing ability of plasma (FRAP), were measured.
The mean age of the subjects was 39.63±13 years in the case group and 39.37±12.62 years in the control group (=0.92). The mean Psoriasis Area and Severity Index (PASI) scores of these groups were 15.27 and 10.47. The mean levels of fasting blood sugar and C-reactive protein were significantly higher in the case group than the control group (=0.04 and =0.02, respectively). Moreover, the mean levels of AGEs and AOPPs in the case group were significantly higher than in the control group (=0.001), while the mean levels of FRAP, PON1, and LCAT were significantly lower in the case group than in the control group (=0.001). There was no significant association between PASI and oxidant or antioxidant markers, except for AOPP, which had a negative association with PASI.
Our findings suggest an imbalance among oxidative stress and antioxidant markers in the pathogenesis of psoriasis. The oxidant-antioxidant enzymatic system is impaired in psoriasis as a result of increased oxidant products and reduced antioxidant activity.
银屑病是一种慢性、免疫介导的炎症性疾病。先前的研究表明氧化应激在银屑病发病机制中可能发挥作用。
我们试图比较银屑病患者的特殊氧化应激和抗氧化标志物。
本研究纳入35例银屑病患者和35名健康对照者。检测了氧化标志物（包括晚期糖基化终末产物（AGEs）和晚期氧化蛋白产物（AOPPs））以及抗氧化酶（包括卵磷脂胆固醇酰基转移酶（LCAT）、对氧磷酶-1（PON1）和血浆铁还原能力（FRAP））的血清水平。
病例组受试者的平均年龄为39.63±13岁，对照组为39.37±12.62岁（P =0.92）。这些组的银屑病面积和严重程度指数（PASI）平均得分分别为15.27和10.47。病例组空腹血糖和C反应蛋白的平均水平显著高于对照组（分别为P =0.04和P =0.02）。此外，病例组AGEs和AOPPs的平均水平显著高于对照组（P =0.001），而病例组FRAP、PON1和LCAT的平均水平显著低于对照组（P =0.001）。除AOPP与PASI呈负相关外，PASI与氧化或抗氧化标志物之间无显著关联。
我们的研究结果表明银屑病发病机制中氧化应激和抗氧化标志物之间存在失衡。由于氧化产物增加和抗氧化活性降低，银屑病患者的氧化-抗氧化酶系统受损。
