Numerous Recurring Angiolipomas in a Patient with a History of Hepatitis B and Hepatocellular Carcinoma.

Angiolipomas are benign vascularized variants of lipomas. They can present as a solitary lesion or in clusters, occurring equally in both male and female patients, often after puberty. Angiolipomas are uncommon and few cases have been documented, especially cases with very high counts or multiple clusters. The clinical presentation is similar to that of lipomas; however, they have distinct histological characteristics with varying levels of vascularity and microthrombi intimately associated with mature adipocytes. Angiolipomas can be further classified as non-infiltrating or infiltrating depending on their encapsulation and relation to other structures. Although the etiology is unknown, angiolipomas have been shown to be associated with systemic disease, such as diabetes mellitus and HIV, and a link to HIV protease inhibitors has also been documented in several case reports. However, no cases have been reported in patients with liver disease before. Herein, we present a rare and unusual case of a male patient with a history of hepatitis B and hepatocellular carcinoma and at least 68 angiolipomas.