Cassarino David, Diep My
Dr. Cassarino is with the Department of Pathology at Kaiser SCPMG in Los Angeles, California.
Mr. Diep is with the College of Osteopathic Medicine of the Pacific, Western University of Health Sciences in Pomona, California.
J Clin Aesthet Dermatol. 2021 Aug;14(8):41-43. Epub 2021 Aug 1.
Angiolipomas are benign vascularized variants of lipomas. They can present as a solitary lesion or in clusters, occurring equally in both male and female patients, often after puberty. Angiolipomas are uncommon and few cases have been documented, especially cases with very high counts or multiple clusters. The clinical presentation is similar to that of lipomas; however, they have distinct histological characteristics with varying levels of vascularity and microthrombi intimately associated with mature adipocytes. Angiolipomas can be further classified as non-infiltrating or infiltrating depending on their encapsulation and relation to other structures. Although the etiology is unknown, angiolipomas have been shown to be associated with systemic disease, such as diabetes mellitus and HIV, and a link to HIV protease inhibitors has also been documented in several case reports. However, no cases have been reported in patients with liver disease before. Herein, we present a rare and unusual case of a male patient with a history of hepatitis B and hepatocellular carcinoma and at least 68 angiolipomas.
血管脂肪瘤是脂肪瘤的良性血管化变体。它们可表现为单个病变或成簇出现，在男性和女性患者中均有发生，常在青春期后出现。血管脂肪瘤并不常见，仅有少数病例被记录，尤其是血管数量非常多或成多个簇状的病例。其临床表现与脂肪瘤相似；然而，它们具有独特的组织学特征，血管化程度不同，且微血栓与成熟脂肪细胞密切相关。根据其包膜情况及与其他结构的关系，血管脂肪瘤可进一步分为非浸润性或浸润性。虽然病因不明，但血管脂肪瘤已被证明与全身性疾病有关，如糖尿病和艾滋病，并且在一些病例报告中也记录了与艾滋病蛋白酶抑制剂的关联。然而，此前尚无肝病患者发生血管脂肪瘤的病例报告。在此，我们报告一例罕见且不寻常的男性患者，该患者有乙肝和肝细胞癌病史，且至少有68个血管脂肪瘤。
