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一名新冠肺炎患者发生脑出血并发肝素诱导的血小板减少症的罕见病例。

A rare case of intracerebral hemorrhage complicating heparin-induced thrombocytopenia in a COVID-19 patient.

作者信息

Zyani A, Elyachioui K, Treyi C, Aabdi M, Sbai H

机构信息

Anesthesiology and Intensive Care Unit, Faculty of Medicine and Pharmacy, Abdelmalek Essaadi University, Tangier, Morocco.

出版信息

Ann Med Surg (Lond). 2021 Dec;72:103070. doi: 10.1016/j.amsu.2021.103070. Epub 2021 Nov 20.

DOI:10.1016/j.amsu.2021.103070
PMID:34840776
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8605820/
Abstract

INTRODUCTION

Heparin-induced thrombocytopenia is a rare complication of heparin therapy associated with thrombocytopenia and mainly thrombotic complications.

CASE REPORT

we herein describe a case of a woman hospitalized for management of a severe case of COVID-19 treated with low molecular weight heparin, who developed heparin-induced thrombocytopenia complicated by intracerebral hemorrhage with no thrombotic complications.

CONCLUSION

Discontinuation of heparin was effective without the use of other non-heparin anticoagulants, platelet transfusion or plasmapheresis.

摘要

引言

肝素诱导的血小板减少症是肝素治疗的一种罕见并发症，与血小板减少症相关，主要为血栓形成并发症。

病例报告

我们在此描述一例因严重新型冠状病毒肺炎住院并接受低分子量肝素治疗的女性病例，该患者发生了肝素诱导的血小板减少症，并并发脑出血，无血栓形成并发症。

结论

停用肝素有效，无需使用其他非肝素抗凝剂、血小板输注或血浆置换。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fffa/8626659/c52b9355afd5/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fffa/8626659/ec6c62f176bd/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fffa/8626659/c52b9355afd5/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fffa/8626659/ec6c62f176bd/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fffa/8626659/c52b9355afd5/gr2.jpg

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本文引用的文献

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Is COVID-19 an Independent Risk Factor for Heparin-Induced Thrombocytopenia?新型冠状病毒肺炎是肝素诱导的血小板减少症的独立危险因素吗？
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COVID-19 patients often show high-titer non-platelet-activating anti-PF4/heparin IgG antibodies.COVID-19 患者常表现出高滴度非血小板活化抗 PF4/肝素 IgG 抗体。
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Bilateral Adrenal Hemorrhage Secondary to Heparin-Induced Thrombocytopenia.肝素诱导的血小板减少继发双侧肾上腺出血
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Heparin-induced thrombocytopenia.肝素诱导的血小板减少症。
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