一名87岁女性获得性因子X缺乏症的罕见病因
A Rare Cause of Acquired Factor X Deficiency in an 87-Year-Old Female.
作者信息
Bangolo Ayrton, Waykole Trupti, Niazi Bilal, Sajja Chandini, Akhter Mahabuba, Gupta Bhavna, Elias Sameh
机构信息
Department of Internal Medicine, Hackensack Meridian Health Palisades Medical Center, 7600 River Road, North Bergen, NJ 07047, USA.
Department of Hematology and Oncology, Hackensack Meridian Health Palisades Medical Center, 7600 River Road, North Bergen, NJ 07047, USA.
出版信息
Case Rep Hematol. 2021 Nov 17;2021:1138329. doi: 10.1155/2021/1138329. eCollection 2021.
Factor X deficiency is a rare coagulopathy that can be inherited or acquired. Acquired factor X deficiency has been associated with plasma cell dyscrasias, amyloids, and use of vitamin K antagonists. Of plasma cell dyscrasias, most cases in the literature have been associated with multiple myeloma with or without concomitant AL amyloidosis. Here, we present a rare case of acquired isolated factor X deficiency in an elderly patient with immunoglobulin A (Ig A) monoclonal gammopathy of undetermined significance (MGUS). Herein, we highlight a rare cause of acquired factor X deficiency, and we hope to contribute to the growing literature of plasma cell dyscrasias associated with factor X deficiency.
因子X缺乏症是一种罕见的凝血病，可遗传或后天获得。后天性因子X缺乏症与浆细胞异常增生症、淀粉样变性及维生素K拮抗剂的使用有关。在浆细胞异常增生症中，文献报道的大多数病例与伴或不伴AL淀粉样变性的多发性骨髓瘤有关。在此，我们报告一例老年患者，患有意义未明的免疫球蛋白A（IgA）单克隆丙种球蛋白病（MGUS），出现后天性孤立性因子X缺乏症。在此，我们强调后天性因子X缺乏症的一种罕见病因，希望能为与因子X缺乏症相关的浆细胞异常增生症的文献增添内容。
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