Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150000, China.
School of Pharmaceutical Sciences, Health Science Center, Shenzhen Technology University, Shenzhen 518060, China.
J Asian Nat Prod Res. 2022 Nov;24(11):1018-1024. doi: 10.1080/10286020.2021.2008371. Epub 2021 Nov 29.
Phytochemical investigation on the concentrate of Huangjing wine, resulted in the isolation of three new tyrosol derivatives 4-hydroxyphenethyl 2-(R)-hydroxy-3-phenylpropionate (), 4-hydroxyphenethyl(4-hydroxy-3-methoxyphenyl)propionate () and 4-hydroxyphenethyl ethyl succinate (), together with 5 known compounds, ferulic acid (), L-phenyllactic acid (), hydroxytyrosol (), dihydroferulic acid (), cyclo(L-Pro-D-Tyr) (). Their structures were elucidated using spectroscopic analysis and by comparison with the literature data. All compounds displayed antioxidant effect in the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical. Among them, the new compound exhibited obvious antioxidant effect, and new compounds and exhibited medium antioxidant effect.
黄精酒浓缩液的植物化学研究，分离得到三个新的酪醇衍生物：4-羟基苯乙基 2-（R）-羟基-3-苯丙酸酯（）、4-羟基苯乙基（4-羟基-3-甲氧基苯基）丙酸酯（）和 4-羟基苯乙基丁二酸酯（），以及 5 种已知化合物：阿魏酸（）、L-苯乳酸（）、羟基酪醇（）、二氢阿魏酸（）、环己基（L-Pro-D-Tyr）（）。它们的结构通过光谱分析和与文献数据的比较来阐明。所有化合物在 DPPH（2,2-二苯基-1-苦基肼）自由基中均显示出抗氧化作用。其中，新化合物 表现出明显的抗氧化作用，新化合物 和 表现出中等的抗氧化作用。
