女性膀胱过度活动症患者尿急与焦虑、抑郁和压力的日常症状关联。
Daily symptom associations for urinary urgency and anxiety, depression and stress in women with overactive bladder.
机构信息
Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
Department of Urology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
出版信息
Int Urogynecol J. 2022 Apr;33(4):841-850. doi: 10.1007/s00192-021-05033-0. Epub 2021 Nov 29.
INTRODUCTION AND HYPOTHESIS
Women with overactive bladder (OAB) report psychological distress, anxiety and depression, but short-term associations between these symptoms are poorly studied. Our objectives were to study daily associations between OAB symptoms and psychological symptoms and test whether these associations were stable when reassessed after 3 months. We hypothesized that OAB symptoms are positively associated with anxiety and depression symptoms over a short-term (daily) basis.
METHODS
Female patients with OAB [bothersome urgency and/or urgency urinary incontinence (UUI)] assessed OAB and mood symptoms at baseline and 3 months using a 3-day bladder diary and visual analog scale (VAS) ratings (0-100 mm) for anxiety, depression and stress. Daily OAB and mood symptom associations were tested using Spearman correlations. Generalized estimating equation (GEE) models tested associations between daily urgency scores and each psychological rating adjusting for covariates, time and a time-symptom interaction term.
RESULTS
Participants (n = 69) had mean (SD) age 63.3 (13.4) years. Baseline diary outcomes [median (IQR)/day] included day voids 8 (7-11), nocturia 0 (0-1), UUI episodes 1 (0-3) and urgency score 1.75 (1-2.25). Anxiety and depression diagnoses (dx) and treatment (tx) were common (anxiety dx 30.4%, tx 21.7%; depression dx 47.8%, tx 37.7%), but daily anxiety, depression and stress ratings were low [median (IQR) mm 10 (3-35), 5 (1-16), and 16 (4-39), respectively]. Daily urgency scores correlated with anxiety (r = 0.30-0.40, days 1-3, p ≤ 0.01 for all), depression (r = 0.24-0.35, p ≤ 0.05 all) and stress (r = 0.27-0.34, p ≤ 0.03 all). GEE models indicated no significant change in these associations between baseline and 3 months, and OAB treatment did not impact the associations.
CONCLUSIONS
Urgency scores were positively associated with same-day ratings of anxiety, depression and stress in OAB patients.
简介和假设
患有膀胱过度活动症（OAB）的女性报告存在心理困扰、焦虑和抑郁，但这些症状之间的短期关联研究甚少。我们的目标是研究 OAB 症状与心理症状之间的日常关联，并测试在 3 个月后重新评估时这些关联是否稳定。我们假设 OAB 症状与焦虑和抑郁症状之间存在短期（每日）的正相关。
方法
使用 3 天膀胱日记和视觉模拟量表（VAS）评分（0-100 毫米），对患有 OAB[令人困扰的尿急和/或急迫性尿失禁（UUI）]的女性患者在基线和 3 个月时评估 OAB 和情绪症状。使用 Spearman 相关分析测试每日 OAB 和情绪症状之间的关联。使用广义估计方程（GEE）模型，调整协变量、时间和时间-症状交互项后，测试每日紧迫性评分与每项心理评分之间的关联。
结果
参与者（n=69）的平均（SD）年龄为 63.3（13.4）岁。基线日记结果[中位数（IQR）/天]包括日排尿次数 8（7-11）、夜间排尿 0（0-1）、UUI 发作 1（0-3）和紧迫性评分 1.75（1-2.25）。焦虑和抑郁诊断（dx）和治疗（tx）很常见（焦虑 dx 30.4%，tx 21.7%；抑郁 dx 47.8%，tx 37.7%），但每日焦虑、抑郁和压力评分较低[中位数（IQR）mm 10（3-35）、5（1-16）和 16（4-39）]。每日紧迫性评分与焦虑（r=0.30-0.40，第 1-3 天，p≤0.01）、抑郁（r=0.24-0.35，p≤0.05）和压力（r=0.27-0.34，p≤0.03）呈正相关。GEE 模型表明，在基线和 3 个月之间，这些关联没有明显变化，并且 OAB 治疗对这些关联没有影响。
结论
在 OAB 患者中，紧迫性评分与当天的焦虑、抑郁和压力评分呈正相关。
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