Wang Jia-Jia, Jin Ai-Hong, Hu Ling-Min, Tu Xiu-Wei, Huang Xiao-Peng, Mo Li-Cai
Department of Traditional Chinese Medicine, Taizhou Hospital of Zhejiang Province Affiliated with Wenzhou Medical University, Linhai, Zhejiang, China.
Department of Nephrology, Ruian City Traditional Chinese Medicine Hospital, Ruian, Zhejiang, China.
Front Neurol. 2025 May 13;16:1537796. doi: 10.3389/fneur.2025.1537796. eCollection 2025.
The association between sleep duration and overactive bladder (OAB) risk remains underexplored. The aim of this study was to assess this relationship in U.S. adults using National Health and Nutrition Examination Survey (NHANES) data.
This cross-sectional study included 24,360 participants aged 20-80 years with OAB who completed the NHANES (2005-2018). NHANES Kidney Conditions-Urology Questionnaire data and the Overactive Bladder Symptom Score (OABSS) were collected. Sleep duration was self-reported by the participants. Propensity score matching (PSM) and multivariate logistic regression were employed to control for confounding variables, whereas a generalized additive model (GAM) was utilized to explore the nonlinear relationship between sleep duration and OAB.
Short sleep (<6 h) significantly increased OAB risk (OR 1.37; 95% CI, 1.21-1.55; < 0.01). A U-shaped relationship between sleep duration and OAB was observed, suggesting that approximately 6 h of sleep is optimal for minimizing OAB risk. Additional risk factors for OAB included female sex, older age, higher BMI, lower education and income levels, hypertension, diabetes, and smoking.
Both insufficient and excessive sleep durations were independently linked to increased OAB risk, and the optimal sleep duration to minimize OAB risk was approximately 6 h. These findings emphasize the importance of targeted prevention and intervention strategies focused on sleep and other modifiable risk factors for OAB. Further research is needed to better understand the biological mechanisms linking sleep duration and OAB.
睡眠时长与膀胱过度活动症（OAB）风险之间的关联仍未得到充分研究。本研究旨在利用美国国家健康与营养检查调查（NHANES）数据评估美国成年人中的这种关系。
这项横断面研究纳入了24360名年龄在20 - 80岁之间且患有OAB并完成NHANES（2005 - 2018年）的参与者。收集了NHANES肾脏疾病 - 泌尿外科问卷数据和膀胱过度活动症症状评分（OABSS）。睡眠时长由参与者自行报告。采用倾向得分匹配（PSM）和多因素逻辑回归来控制混杂变量，同时利用广义相加模型（GAM）来探索睡眠时长与OAB之间的非线性关系。
短睡眠（<6小时）显著增加OAB风险（OR 1.37；95%CI，1.21 - 1.55；P < 0.01）。观察到睡眠时长与OAB之间呈U形关系，表明大约6小时的睡眠对于将OAB风险降至最低最为理想。OAB的其他风险因素包括女性、老年、较高的体重指数、较低的教育和收入水平、高血压、糖尿病和吸烟。
睡眠不足和睡眠过长均与OAB风险增加独立相关，将OAB风险降至最低的最佳睡眠时长约为6小时。这些发现强调了针对睡眠和OAB其他可改变风险因素的针对性预防和干预策略的重要性。需要进一步研究以更好地理解连接睡眠时长与OAB的生物学机制。
