Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg 3084, Victoria, Australia; Mercy Perinatal, Mercy Hospital for Women, Victoria, Australia.
Mercy Perinatal, Mercy Hospital for Women, Victoria, Australia.
Pregnancy Hypertens. 2022 Mar;27:23-26. doi: 10.1016/j.preghy.2021.11.006. Epub 2021 Nov 17.
Activin A is aberrantly expressed by the preeclamptic placenta and circulating levels have been investigated as a potential biomarker for the disease. In a nested case-control study we measured Activin A levels in maternal plasma at 28- and 36-weeks' gestation preceding term preeclampsia diagnosis. At 28 weeks Activin A was not significantly altered (n = 73 destined to develop preeclampsia vs n = 191 controls). At 36 weeks' gestation Activin A was significantly increased in 40 women destined to develop preeclampsia relative to 201 controls (p < 0.0001). These findings provide further validation of Activin A as a potential biomarker for subsequent term preeclampsia.
激活素 A 在子痫前期胎盘异常表达，其循环水平已被作为疾病的潜在生物标志物进行了研究。在一项巢式病例对照研究中，我们在早产子痫前期诊断前的 28 周和 36 周时测量了母体血浆中的激活素 A 水平。在 28 周时，激活素 A 没有明显改变（子痫前期患者 n=73，对照组 n=191）。在 36 周时，40 名子痫前期患者的激活素 A 水平明显高于 201 名对照组（p<0.0001）。这些发现进一步验证了激活素 A 作为潜在的生物标志物用于预测随后的足月子痫前期。
