Decker Jilyan, Cavanaugh Amanda, Brown Megan, Ligato Saverio, Serrano Oscar Kenneth
Department of Surgery, University of Connecticut School of Medicine, Farmington, CT, United States.
Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, CT, United States.
Ann Hepatobiliary Pancreat Surg. 2021 Nov 30;25(4):556-561. doi: 10.14701/ahbps.2021.25.4.556.
Intraductal tubulopapillary neoplasms (ITPNs) of the pancreas and biliary tract are rare pre-malignant entities of the biliary tract and pancreas that are difficult to diagnose preoperatively. While there are imaging characteristics that can differentiate these lesions from more common entities like adenocarcinoma or intraductal papillary mucinous neoplasms (IPMN), ITPNs are not always distinctive. Herein we present two cases of ITPN, one of biliary and the other of pancreatic origin, which had a preoperative diagnosis of cholangiocarcinoma and IPMN, respectively. We discuss our findings in these cases, patient presentation and course, review the radiographic and pathologic findings, and propose a more effective approach to the preoperative workup and diagnosis of ITPN based on our review of the contemporary literature.
胰腺和胆道的导管内管状乳头状肿瘤（ITPNs）是胆道和胰腺罕见的癌前病变，术前难以诊断。虽然有一些影像学特征可将这些病变与腺癌或导管内乳头状黏液性肿瘤（IPMN）等更常见的病变区分开来，但ITPNs并不总是具有特异性。在此，我们报告两例ITPN，一例起源于胆道，另一例起源于胰腺，术前分别诊断为胆管癌和IPMN。我们讨论这些病例的研究结果、患者表现和病程，回顾影像学和病理结果，并根据对当代文献的回顾，提出一种更有效的ITPN术前检查和诊断方法。
