母亲高血压对新生儿早期血小板计数的影响。

The effects of maternal hypertension on the early neonatal platelet count.

作者信息

Joslyn Peter, Rosenbaum Cornelius, Chapple Andrew G, Heard Asha, Velez Maria, Barkemeyer Brian

机构信息

Department of Pediatrics Division of Neonatology, Louisiana State University Health Sciences Center New Orleans, New Orleans, LA, USA.

Biostatistics Program, School of Public Health, Louisiana State University Health Sciences Center New Orleans, New Orleans, LA, USA.

出版信息

J Perinatol. 2022 Jun;42(6):796-802. doi: 10.1038/s41372-021-01278-1. Epub 2021 Nov 29.

DOI:10.1038/s41372-021-01278-1

PMID:34845295

Abstract

OBJECTIVE

To examine the relationship between maternal hypertension and early neonatal platelet counts.

STUDY DESIGN

This single site retrospective cohort study compared initial platelet counts in the first day of life of infants born to mothers with preeclampsia with severe features (PSF) (n = 224) and infants born to normotensive mothers using multivariable logistic and Quasi-Poisson regression models.

RESULT

There was no statistical difference in initial platelet counts or likelihood of thrombocytopenia (aOR = 1.19, 95% CI 0.68-2.08) between infants born to mothers with PSF and infants born to normotensive mothers after multivariable adjustment. Initial platelet counts and thrombocytopenia risk were unaffected by the presence of maternal end organ dysfunction. Small for gestational age (SGA) status was the most significant risk factor for the development of thrombocytopenia (aOR = 2.24, 95% CI 1.13-4.30).

CONCLUSION

Maternal PSF does not directly affect neonatal initial platelet counts. SGA status confers the greatest risk of early thrombocytopenia.

摘要

目的

探讨母亲高血压与新生儿早期血小板计数之间的关系。

研究设计

这项单中心回顾性队列研究，采用多变量逻辑回归和拟泊松回归模型，比较了患有重度子痫前期（PSF）的母亲所生婴儿（n = 224）与血压正常的母亲所生婴儿出生第一天的初始血小板计数。

结果

多变量调整后，患有PSF的母亲所生婴儿与血压正常的母亲所生婴儿在初始血小板计数或血小板减少的可能性方面无统计学差异（调整后比值比[aOR]=1.19，95%置信区间[CI]为0.68 - 2.08）。母亲终末器官功能障碍的存在并不影响初始血小板计数和血小板减少风险。小于胎龄（SGA）状态是发生血小板减少的最显著危险因素（aOR = 2.24，95% CI为1.13 - 4.30）。