伴有和不伴有卒中的椎基底动脉延长扩张症患者血清基质金属蛋白酶-2 和基质金属蛋白酶-9 水平：病例对照研究。
Matrix metalloproteinase-2 and matrix metalloproteinase-9 serum levels in patients with vertebrobasilar dolichoectasia with and without stroke: case-control study.
机构信息
Neurology Department, Instituto Mexicano del Seguro Social (IMSS), HGZ 2, Av. de, Los Conos 102, Ojocaliente, 20190, Aguascalientes, Mexico.
Departamento de Bioquímica, Facultad de Medicina Mexicali, Universidad Autónoma de Baja California, Mexicali, Mexico.
出版信息
Neuroradiology. 2022 Jun;64(6):1187-1193. doi: 10.1007/s00234-021-02869-7. Epub 2021 Nov 29.
PURPOSE
To describe the differences in the serum levels of MMP-2 and MMP-9 of patients with vertebrobasilar dolichoectasia (VBD) with and without acute stroke.
METHODS
Case-control study. From an outpatient clinic, we recruited 14 controls and 19 patients with VBD. We also recruited 33 patients with stroke from two emergency departments, 14 without VBD (S/-VBD) and 19 with VBD (S/ + VBD). All the patients underwent serum MMP-2 and MMP-9 measurements and a non-contrast CT scan. Two investigators assessed the intracranial vertebral arteries (VA) and the basilar artery (BA) at the mid-pons. Diagnosis of VBD was made if the BA diameter was ≥ 4.5 mm.
RESULTS
The mean age of the 66 patients studied was 57.6 + 16.0 years, 41% female. In the 33 patients with stroke, the median NIHSS was 8 (range 15); there were no differences in the NIHSS scores between both groups with stroke. Median MMP-2 levels were lower in the S/-VBD when compared to controls. Median MMP-9 serum levels were higher in both groups with VBD when compared to controls and the S/-VDB group. Both groups with stroke exhibited higher MMP-9 serum levels than controls but were not statistically different from those found in patients with VBD. Serum levels of MMP-9 were significantly correlated with the diameters of the BA (r = 0.344, p = 0.01) and the left VA (r = 0.305, p = 0.05).
CONCLUSION
This study found that high serum levels of MMP-9 are associated with VBD independently of stroke and correlated with the degree of VBD.
目的
描述伴有和不伴有急性脑卒中的椎基底动脉延长扩张症（VBD）患者血清基质金属蛋白酶-2（MMP-2）和 MMP-9 水平的差异。
方法
病例对照研究。我们从一个门诊招募了 14 名对照者和 19 名 VBD 患者，还从两个急诊部门招募了 33 名脑卒中患者，其中 14 名无 VBD（S/-VBD），19 名有 VBD（S/ + VBD）。所有患者均进行了血清 MMP-2 和 MMP-9 测量和非对比 CT 扫描。两位研究者评估了桥脑中部的颅内椎动脉（VA）和基底动脉（BA）。如果 BA 直径≥4.5mm，则诊断为 VBD。
结果
研究的 66 名患者的平均年龄为 57.6 + 16.0 岁，41%为女性。在 33 名脑卒中患者中，NIHSS 中位数为 8（范围 15）；两组脑卒中患者的 NIHSS 评分无差异。与对照组相比，S/-VBD 患者的 MMP-2 水平中位数较低。与对照组和 S/-VDB 组相比，两组 VBD 患者的 MMP-9 血清水平均较高。两组脑卒中患者的 MMP-9 血清水平均高于对照组，但与 VBD 患者无统计学差异。MMP-9 血清水平与 BA（r = 0.344，p = 0.01）和左侧 VA（r = 0.305，p = 0.05）的直径显著相关。
结论
本研究发现，MMP-9 血清水平升高与 VBD 有关，与脑卒中无关，与 VBD 的严重程度相关。
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