Collegium Medicum in Bydgoszcz, Nicolaus University, Torun, Poland.
10 Military Research Hospital in Bydgoszcz, Bydgoszcz, Poland.
Adv Ther. 2022 Jan;39(1):140-147. doi: 10.1007/s12325-021-01939-9. Epub 2021 Nov 29.
Triple whammy (TW) is a potentially dangerous drug combination that can lead to acute kidney injury (AKI). This drug interaction (DI) occurs when angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) are used together with diuretics and non-steroidal anti-inflammatory drugs (NSAIDs). One of the most serious consequences of TW DI is an increased risk of developing pre-renal acute kidney injury (pr-AKI). The term TW, in the context of a DI affecting kidney function, is not very widespread. The aim of this article was to gather information on this interaction. Previous knowledge on the mechanism of TW and how to increase patient awareness of this interaction is described. In addition, the specific nature of the acute kidney injury (AKI) caused by triple whammy (AKITW) is presented. On the basis of the current state of knowledge, recommendations on how to manage the TW DI are also demonstrated.
三联打击（TW）是一种潜在的危险药物组合，可导致急性肾损伤（AKI）。当血管紧张素转换酶抑制剂（ACEIs）或血管紧张素 II 受体阻滞剂（ARBs）与利尿剂和非甾体抗炎药（NSAIDs）一起使用时，就会发生这种药物相互作用（DI）。TW DI 最严重的后果之一是增加发生肾前急性肾损伤（pr-AKI）的风险。在影响肾功能的 DI 中，“三联打击”这个术语并不是很常见。本文的目的是收集关于这种相互作用的信息。本文描述了之前关于 TW 作用机制的知识，以及如何提高患者对此相互作用的认识。此外，还介绍了由三联打击（AKITW）引起的急性肾损伤（AKI）的具体性质。基于目前的知识状况，还展示了如何管理 TW DI 的建议。
