Cancer & Translational Research Lab, Dr. D. Y. Patil Biotechnology & Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune 411033, Maharashtra, India.
Department of Oral Pathology & Microbiology, Dr. D.Y. Patil Dental College & Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Pimpri, Pune 411018, India.
Future Oncol. 2021 Dec;17(36):5129-5134. doi: 10.2217/fon-2020-0532. Epub 2021 Nov 30.
Accumulating evidence suggests the role of cellular components in achieving antitumor to protumor microenvironments. Among the various types of cells within the tumor niche, the state of CD8 T cells apparently changes from cytotoxic T effector cells and memory T cells to exhausted CD8 T cells. These changes in the phenotype of CD8 T cells promote the protumor microenvironment. Recently, comprehensive experimental data delineated the role of thymocyte selection-associated high-mobility group-box protein (TOX), which regulates the transcriptional process and epigenetic remodeling, with implications in tumor and chronic viral infections. This perspective summarizes the molecular mechanisms that link CD8 T cells, TOX, and transcriptional and epigenetic reprogramming as well as future directions for determining new avenues of cancer therapeutics.
越来越多的证据表明细胞成分在实现抗肿瘤和促肿瘤微环境中的作用。在肿瘤生态位内的各种类型的细胞中，CD8 T 细胞的状态显然从细胞毒性 T 效应细胞和记忆 T 细胞转变为耗竭的 CD8 T 细胞。CD8 T 细胞表型的这些变化促进了促肿瘤微环境。最近，全面的实验数据描绘了胸腺细胞选择相关高迁移率族盒蛋白（TOX）的作用，该蛋白调节转录过程和表观遗传重塑，对肿瘤和慢性病毒感染有影响。本观点总结了将 CD8 T 细胞、TOX 以及转录和表观遗传重编程联系起来的分子机制，并为确定癌症治疗的新途径指明了方向。
