供体-受体复合物实现的可见光促进的烯烃羟基二氟烷基化反应
Visible-Light-Promoted Hydroxydifluoroalkylation of Alkenes Enabled by Electron Donor-Acceptor Complex.
作者信息
Xie Zhen-Zhen, Zheng Yu, Tang Kai, Guan Jian-Ping, Yuan Chu-Ping, Xiao Jun-An, Xiang Hao-Yue, Chen Kai, Chen Xiao-Qing, Yang Hua
机构信息
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P.R. China.
College of Chemistry and Materials Science, Nanning Normal University, Nanning 530001, Guangxi P.R. China.
出版信息
Org Lett. 2021 Dec 17;23(24):9474-9479. doi: 10.1021/acs.orglett.1c03655. Epub 2021 Nov 30.
A catalyst-free strategy for regioselective hydroxydifluoroalkylation of alkenes with alkyl bromides was developed, affording a series of difluoroalkylated tertiary alcohols in moderate to good yields. This photocatalyst-free protocol shows broad substrate scope under mild conditions. Moreover, mechanistic studies revealed that a newly identified electron donor-acceptor complex is crucial to this transformation.
开发了一种无催化剂的策略，用于烯烃与溴代烷烃的区域选择性羟基二氟烷基化反应，以中等至良好的产率得到了一系列二氟烷基化叔醇。这种无光催化剂的方法在温和条件下显示出广泛的底物范围。此外，机理研究表明，一种新发现的电子供体-受体络合物对这种转化至关重要。
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