School of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
University of Florence, Department of Chemistry "Ugo Shiff", Via della Lastruccia 13, 1-50019 Sesto Fiorentino, Italy.
Org Biomol Chem. 2021 Dec 15;19(48):10565-10569. doi: 10.1039/d1ob02153b.
Glutathione peroxidase (GPx) regulates cellular peroxide levels through glutathione oxidation. GPx-mimics based on 4,5-disubstituted fluorene diselenides, their oxides, and ditellurides show catalytic activities consistent with conformational restriction about the dichalcogen bond.
谷胱甘肽过氧化物酶 (GPx) 通过氧化谷胱甘肽来调节细胞内过氧化物水平。基于 4,5-二取代芴二硒化物、其氧化物和二碲化物的 GPx 模拟物表现出与二硫键构象限制一致的催化活性。
