Tavassoli M
Exp Hematol. 1978 Mar;6(3):257-69.
The last step in mammalian erythropoiesis consists of nuclear elimination and delivery of the non-nucleated red cell (reticulocyte) into the circulation. This is accomplished by migration of reticulocytes through the wall of the vascular sinuses which forms an anatomical barrier between the hemopoietic compartment and the circulation. This barrier is instrumental in a complicated mechanism to ensure orderly traffic of new cells in response to the requirement of the organism. Thus, it exerts a control over which cells will migrate into the vascular lumen and when they will do so. Defective red cells and nucleated red cells are prevented from migration; even normal reticulocytes may be temporarily held back if their presence in the circulation would exceed the requirement of the body. Little is known about how this barrier operates to control the red cell delivery. Literature relevant to this subject has been reviewed and an attempt is made to formulate some basic questions in this area.
哺乳动物红细胞生成的最后一步包括细胞核的清除以及将无核红细胞（网织红细胞）释放到循环系统中。这是通过网织红细胞穿过血管窦壁来实现的，血管窦壁在造血区室和循环系统之间形成了解剖学屏障。该屏障在一个复杂机制中发挥作用，以确保根据机体需求使新细胞有序流通。因此，它对哪些细胞将迁移到血管腔以及何时迁移施加控制。有缺陷的红细胞和有核红细胞被阻止迁移；如果正常网织红细胞在循环系统中的数量超过身体需求，它们甚至可能会被暂时滞留。关于这个屏障如何运作以控制红细胞释放，目前所知甚少。已对与该主题相关的文献进行了综述，并试图提出该领域的一些基本问题。
