降钙素基因相关肽对食物摄入的影响涉及厌恶机制。

The effect of calcitonin gene-related peptide on food intake involves aversive mechanisms.

作者信息

Krahn D D, Gosnell B A, Levine A S, Morley J E

出版信息

Pharmacol Biochem Behav. 1986 Jan;24(1):5-7. doi: 10.1016/0091-3057(86)90035-3.

Abstract

Calcitonin gene-related peptide (CGRP), the product of the calcitonin gene produced primarily in the central nervous system, has been shown to decrease food intake when administered intracerebroventricularly (ICV). Testing of CGRP (ICV) in both single bottle conditioned-aversion and differential starvation paradigms was done. In both paradigms, results using CGRP were consistent with those predicted for aversive agents. Therefore, CGRP apparently decreases feeding via aversive mechanisms.

摘要

降钙素基因相关肽（CGRP）是主要在中枢神经系统产生的降钙素基因的产物，已表明当脑室内（ICV）给药时可减少食物摄入量。已在单瓶条件性厌恶和差异饥饿范式中对CGRP（ICV）进行了测试。在这两种范式中，使用CGRP的结果与对厌恶剂预测的结果一致。因此，CGRP显然通过厌恶机制减少进食。