Cellular Pathology, Queen's Hospital, Romford, London, UK
BMJ Case Rep. 2021 Nov 30;14(11):e246374. doi: 10.1136/bcr-2021-246374.
Signet ring cell carcinoma, in general, is a peculiar tumour. There is always a query regarding its exact site of origin. Even, immunohistochemistry shows overlapping staining patterns between various sites. On one hand, signet ring cell carcinoma of the bladder is a rare occurrence, but on the other hand metastatic signet ring cell carcinoma to the bladder is not uncommon. However, without prior knowledge of the primary site of tumour clinically and radiologically, definitive diagnosis is challenging based on morphology and immunohistochemistry.
印戒细胞癌通常是一种特殊的肿瘤。它的起源部位总是存在疑问。即使免疫组织化学显示出不同部位的重叠染色模式。一方面，膀胱癌中的印戒细胞癌是一种罕见的情况，但另一方面，转移性印戒细胞癌到膀胱并不罕见。然而，在没有临床和放射学上对肿瘤的原始部位的了解的情况下，基于形态学和免疫组织化学，明确诊断是具有挑战性的。
