真实世界中老年转移性结直肠癌患者接受替氟尿苷/替匹嘧啶治疗的疗效和安全性。

The Efficacy and Safety of Trifluridine/Tipiracil Treatment for Elderly Patients With Metastatic Colorectal Cancer in a Real-world Setting.

机构信息

Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan;

Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

出版信息

Anticancer Res. 2021 Dec;41(12):6211-6216. doi: 10.21873/anticanres.15440.

DOI:10.21873/anticanres.15440

PMID:34848475

Abstract

BACKGROUND/AIM: Recently, trifluridine/tipiracil (FTD/TPI) treatment was established as a later-line treatment for metastatic colorectal cancer (mCRC). However, FTD/TPI treatment is frequently associated with hematological toxicity. The aim of this study was to evaluate the efficacy and safety of FTD/TPI in elderly patients with mCRC in a real-world setting.

PATIENTS AND METHODS

We retrospectively reviewed the medical records of 74 patients with mCRC who were treated with FTD/TPI.

RESULTS

The treatment effect of the elderly patient group was not inferior to that of the younger patient group. Although the incidence of hematological toxicity in the elderly patient group was higher than that in the younger patient group, there were no significant differences in the rate of treatment discontinuation due to adverse events between the two groups.

CONCLUSION

In elderly patients with mCRC, FTD/TPI treatment was effective for prolonging survival. However, it should be noted that elderly patients showed a higher rate of hematological toxicity than younger patients.

摘要

背景/目的：最近，替比氟尿苷/盐酸拓扑替康（FTD/TPI）治疗被确立为转移性结直肠癌（mCRC）的二线治疗方法。然而，FTD/TPI 治疗常伴有血液学毒性。本研究旨在评估 FTD/TPI 在真实世界环境下治疗老年 mCRC 患者的疗效和安全性。