Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Division of Hematology and Oncology, Department of Medicine, College of Medicine, Gainesville, Florida.
Clin Cancer Res. 2022 Feb 1;28(3):438-440. doi: 10.1158/1078-0432.CCR-21-3564. Epub 2021 Nov 30.
Detection of circulating tumor DNA (ctDNA) postoperatively is prognostic for recurrence for patients with stage III colon cancer. Those with sustained undetectable ctDNA will likely be cured. Eradication of minimal residual disease (per ctDNA clearance) with chemotherapy did not occur in most ctDNA-positive patients and led to eventual disease relapse..
术后循环肿瘤 DNA（ctDNA）的检测对 III 期结肠癌患者的复发具有预后意义。那些持续检测不到 ctDNA 的患者可能会被治愈。大多数 ctDNA 阳性患者未能通过化疗清除微小残留病灶（ctDNA 清除），导致最终疾病复发。
