Jansky L
Experientia Suppl. 1978;32:169-75.
Physiological significance and mechanisms controlling thermogenesis due to substances other than norepinephrine (NE) are considered. Epinephrine (E) induces a strong calorigenic effect, which is potentiated by cold adaptation to the level observed after application of NE. Thermogenesis due to E is located to a great extent in visceral organs. Cold acclimation increases the component of epinephrine thermogenesis located in the brown adipose tissue and non-visceral organs, predominantly. Although E and NE act on the same thermogenic effector, their effect is realized via different regulatory sites. Steroid hormones are not necessary for inducing cold resistance and thermogenesis due to NE. The permissive role of steroids and other substances in inducing changes in enzyme activity and synthesis during various cold stress is discussed.
本文探讨了除去甲肾上腺素（NE）之外的其他物质引起产热的生理意义及调控机制。肾上腺素（E）可诱导强烈的产热效应，冷适应可将其增强至应用NE后所观察到的水平。E引起的产热在很大程度上发生在内脏器官。冷驯化主要增加了位于棕色脂肪组织和非内脏器官的肾上腺素产热成分。尽管E和NE作用于相同的产热效应器，但其作用是通过不同的调节位点实现的。类固醇激素并非NE诱导抗寒和产热所必需的。本文还讨论了类固醇和其他物质在各种冷应激期间诱导酶活性和合成变化中的允许作用。
