Fried R C, Bailey P M, Mullen J L, Stein T P, Crosby L O, Buzby G P
Arch Surg. 1986 Feb;121(2):173-8. doi: 10.1001/archsurg.1986.01400020059007.
Metabolic rates and substrate utilization patterns were evaluated by using a rate cecal ligation and perforation model. Animals that survived for 48 hours after the induction of sepsis were hypermetabolic and responded appropriately to varying exogenous substrate infusions. In contrast, animals that did not survive to 48 hours were premorbidly hypometabolic and failed to adjust their oxidation patterns in response to the exogenous substrate supply. These findings suggest the benefit of individually tailoring the supply of exogenous nutrients in critically ill patients with sepsis and of frequent reassessment of metabolic parameters, including the resting energy expenditure and respiratory quotient.
通过使用盲肠结扎和穿孔模型评估代谢率和底物利用模式。在脓毒症诱导后存活48小时的动物处于高代谢状态，并且对外源性不同底物输注有适当反应。相比之下，未存活至48小时的动物病前处于低代谢状态，并且未能根据外源性底物供应调整其氧化模式。这些发现提示，对于患有脓毒症的危重症患者，个体化调整外源性营养供应以及频繁重新评估包括静息能量消耗和呼吸商在内的代谢参数具有益处。
