关节内富血小板血浆与皮质类固醇注射治疗骶髂关节痛的疗效比较：一项双盲、随机临床试验。

Intra-Articular Platelet Rich Plasma vs Corticosteroid Injections for Sacroiliac Joint Pain: A Double-Blinded, Randomized Clinical Trial.

机构信息

Department of Orthopaedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, California.

Department of Rehabilitation and Regenerative Medicine, Columbia University Medical Center, New York, New York.

出版信息

Pain Med. 2022 Jul 1;23(7):1266-1271. doi: 10.1093/pm/pnab332.

DOI:10.1093/pm/pnab332

PMID:34850180

Abstract

OBJECTIVE

Using stringent inclusion criteria, a double-blinded study protocol, and fluoroscopically guided injections, we compare intra-articular sacroiliac joint platelet-rich plasma injections with intra-articular steroids.

DESIGN

Double-blind, randomized controlled trial.

SETTING

Two large university-based interdisciplinary spine centers.

SUBJECTS

A total of 26 patients with a positive diagnostic block (>80% relief).

METHODS

Subjects who had a positive diagnostic block were randomized to undergo either a fluoroscopically guided intra-articular injection of steroid or a platelet-rich plasma injection. Follow-up was at 1 month, 3 months, and 6 months. Outcomes included level of pain, as indicated on a 0- to 100-mm numeric pain rating scale, and functional disability score, obtained via the Oswestry Disability Index (ODI).

RESULTS

At 1, 3, and 6 months, both groups improved; however, subjects who received steroid injections reported lower pain scores than did subjects who received platelet-rich plasma. Using categorical data, we observed significantly more responders (defined as pain scores that improved by 50% or more from baseline) at 1 and 3 months in the group who received steroids than in the group who received platelet-rich plasma.

CONCLUSION

Although both groups showed improvements in pain and function, the steroid group had significantly greater response and significantly more responders than did the platelet-rich plasma group.

摘要