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口腔癌检测诊断技术的进展。

Advancements in diagnostic techniques for oral cancer detection.

机构信息

Department of Public Health Dentistry, Kalinga Institute of Dental Science, KIIT Deemed to be University, Bhubaneswar, India.

Department of Public Health Dentistry, Kalinga Institute of Dental Science, KIIT Deemed to be University, Bhubaneswar, India -

出版信息

Minerva Dent Oral Sci. 2022 Jun;71(3):192-198. doi: 10.23736/S2724-6329.21.04637-4. Epub 2021 Dec 1.

Abstract

Oral malignancy is among the highest prevalent malignancies all over the world. In comparison to systemic malignancies such as lung cancer and colon cancer, they are frequently overlooked by the general public. Nevertheless, they can be exceedingly lethal if left ignored, regardless at the early stage of the condition. Dentists are the finest qualified healthcare specialists in this sector and are responsible for detecting benign and potentially malignant oral conditions such as oral cancers. Oral carcinoma's high prevalence and delayed appearance are serious international medical concerns. Early detection and management of oral carcinoma are the key goals of the World Health Organization (WHO). The identification of key clinical manifestations during the preliminary oral examination can enhance the patient's likelihood of living. Unfortunately, the conventional technology's practical value is limited by a number of drawbacks. Current advancements in optical scanning techniques, such as tissue-fluorescence imaging and optical coherence tomography, have proven to be quite effective. In particular, nanoparticle-based immunosensors, genomics, and salivary biomarkers, epigenetics and microarray have all received a lot of attention. Raising awareness about frequent dental examinations and using noninvasive, effective, and cost-effective screening tools would improve initial stage detection of oral carcinoma and improve patients' longevity.

摘要

口腔恶性肿瘤是全球最常见的恶性肿瘤之一。与肺癌、结肠癌等系统性恶性肿瘤相比,公众往往容易忽视它们。然而,如果忽视这些肿瘤,即使在疾病早期,它们也可能极具致命性。牙医是这一领域最有资格的医疗保健专家,负责检测口腔良恶性疾病,如口腔癌。口腔癌的高发病率和出现较晚是国际医学界严重关注的问题。世界卫生组织(WHO)的主要目标是早期发现和治疗口腔癌。在初步口腔检查中识别关键的临床表现可以提高患者的生存几率。不幸的是,传统技术的实际价值受到了许多缺点的限制。目前,组织荧光成像和光学相干断层扫描等光学扫描技术的进步已被证明非常有效。特别是,基于纳米粒子的免疫传感器、基因组学和唾液生物标志物、表观遗传学和微阵列都受到了广泛关注。提高对定期牙科检查的认识并使用非侵入性、有效且具有成本效益的筛选工具,将改善口腔癌的早期发现并提高患者的寿命。

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