非传染性疾病累积负担预测 HIV 感染者的 COVID 住院情况：一项为期一年的回顾性队列研究。
Cumulative burden of non-communicable diseases predicts COVID hospitalization among people with HIV: A one-year retrospective cohort study.
机构信息
Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, Connecticut, United States of America.
Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America.
出版信息
PLoS One. 2021 Dec 1;16(12):e0260251. doi: 10.1371/journal.pone.0260251. eCollection 2021.
There continue to be conflicting data regarding the outcomes of people with HIV (PWH) who have COVID-19 infection with most studies describing the early epidemic. We present a single site experience spanning a later timeframe from the first report on January 21, 2020 to January 20, 2021 and describe clinical outcomes and predictors of hospitalization among a cohort of PWH in an urban center in Connecticut, USA. Among 103 PWH with controlled HIV disease, hospitalization occurred in 33% and overall mortality was 1%. HIV associated factors (CD4 count, HIV viral suppression) were not associated with hospitalization. Chronic lung disease (OR: 3.35, 95% CI:1.28-8.72), and cardiovascular disease (OR: 3.4, 95% CI:1.27-9.12) were independently associated with hospitalization. An increasing number of non-communicable comorbidities increased the likelihood of hospitalization (OR: 1.61, 95% CI:1.22-2.13).
关于感染 COVID-19 的艾滋病毒感染者（PWH）的结局，仍存在相互矛盾的数据，大多数研究描述的是早期疫情。我们报告了一项来自美国康涅狄格州一个城市中心的单一地点的经验，该经验跨越了从 2020 年 1 月 21 日首次报告到 2021 年 1 月 20 日的时间段，描述了 PWH 队列中的临床结局和住院预测因素。在 103 名 HIV 得到控制的 PWH 中，33%的人住院，总死亡率为 1%。与 HIV 相关的因素（CD4 计数、HIV 病毒抑制）与住院无关。慢性肺部疾病（OR：3.35，95%CI：1.28-8.72）和心血管疾病（OR：3.4，95%CI：1.27-9.12）与住院独立相关。非传染性合并症的数量增加增加了住院的可能性（OR：1.61，95%CI：1.22-2.13）。
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