Waclawiczek H W, Boeckl O
Zentralbl Chir. 1986;111(1):16-24.
Fibrin sealing was applied in 615 cases to patients in the Surgery I Department of Salzburg County Hospitals, between April 1st, 1978 and April 30th, 1985. Fibrin glue Tissucol (Immuno, Vienna) was used in all cases. Need for additional sealing of sutures and anastomoses (n = 331), haemostasis and wound dressing on parenchymatous organs (n = 125), and glueing of skin grafts (n = 97) were the most common indications. Postoperative complications occurred to eight cases (6.4 per cent) in the wake of haemostatic glueing of parenchymatous organs, with lethality being 1.6 per cent (n = 2). One of the patients had to be relaparotomised. Fistulation, following additional sealing of anastomoses and sutures, was recorded from 4.9 per cent of the patients, with the rate of lethality being 0.6 per cent. Inadequate healing of skin grafts was observed in eleven per cent of all cases. Side effects of the fibrin sealant, say, hepatitis, were not observed at all.
1978年4月1日至1985年4月30日期间，萨尔茨堡县医院第一外科的615例患者接受了纤维蛋白封闭治疗。所有病例均使用了纤维蛋白胶Tissucol（Immuno，维也纳）。最常见的适应证包括对缝线和吻合口进行额外封闭（n = 331）、实质器官的止血和伤口敷料（n = 125）以及皮肤移植的粘贴（n = 97）。实质器官止血粘贴后有8例（6.4%）发生术后并发症，致死率为1.6%（n = 2）。其中1例患者不得不再次剖腹手术。吻合口和缝线额外封闭后，4.9%的患者出现了瘘管形成，致死率为0.6%。在所有病例中，11%观察到皮肤移植愈合不良。完全未观察到纤维蛋白密封剂的副作用，如肝炎。
