Department of Ophthalmology, Hanyang University Hospital, Hanyang University College of Medicine, 222 Wangsipli-ro, Seongdong-gu, Seoul, 04763, Republic of Korea.
Sci Rep. 2021 Dec 1;11(1):23249. doi: 10.1038/s41598-021-02726-w.
In this study, we evaluated the topographic pattern of retinal edema in eyes with macular edema (ME) secondary to branch retinal vein occlusion (BRVO) using a widefield retinal thickness map of optical coherence tomography and its association with ME recurrence. In 87 eyes with ME secondary to BRVO who were treated with anti-vascular endothelial growth factor (VEGF) injections and followed up for ≥ 1 years, 12 × 9 mm macular volume scans of swept-source optical coherence tomography (DRI-OCT Triton; Topcon Inc, Japan) were performed and retinal thickness maps were automatically generated at baseline and follow-up visits. Topographic patterns of retinal edema on the maps at baseline and 1 month after the first anti-vascular endothelial growth factor (VEGF) treatment were classified as extramacular (outside the ETDRS grid), macular (within the grid), and combined pattern and correlated with ME recurrences. Seventy-five of 87 (86.2%) eyes with BRVO ME showed combined edema at baseline. There were 4 topographic patterns of edema at 1 month following anti-VEGF injection as follows: no residual edema, extramacular only, macular only, and combined edema. In contrast to the baseline pattern, the pattern of retinal edema 1 month following anti-VEGF therapy showed significant association with 6-month recurrence, number of ME recurrences during a 1-year period, and time to first recurrence. (all P < 0.05) An automatically generated widefield retinal thickness map could be used to effectively visualize the topographic patterns of retinal edema in eyes with BRVO. The map can be used as a valuable tool for detection of retinal edema on widefield retinal areas and prediction of ME recurrence in eyes with BRVO.
在这项研究中，我们使用光学相干断层扫描（OCT）的广角视网膜厚度图评估了分支视网膜静脉阻塞（BRVO）继发的黄斑水肿（ME）眼中的视网膜水肿的地形模式，并研究了其与 ME 复发的关系。在 87 例接受抗血管内皮生长因子（VEGF）注射治疗并随访至少 1 年的 BRVO 继发 ME 患者的眼中，对 12×9mm 的黄斑体积扫描进行了扫频源光学相干断层扫描（DRI-OCT Triton；Topcon Inc，日本），并在基线和随访时自动生成视网膜厚度图。在基线和首次抗 VEGF 治疗后 1 个月时，根据地图上的视网膜水肿地形图模式将其分为黄斑外（不在 ETDRS 网格内）、黄斑内（在网格内）和混合模式，并与 ME 复发相关。87 例 BRVO ME 患者中有 75 例（86.2%）在基线时表现为混合性水肿。在接受抗 VEGF 注射后 1 个月时，有 4 种水肿地形图模式：无残留水肿、仅黄斑外、仅黄斑内和混合性水肿。与基线模式相比，抗 VEGF 治疗 1 个月后的视网膜水肿模式与 6 个月复发、1 年内 ME 复发次数以及首次复发时间均有显著相关性（均 P<0.05）。自动生成的广角视网膜厚度图可有效观察 BRVO 患者的视网膜水肿的地形模式。该图可作为检测 BRVO 患者广角视网膜区域内视网膜水肿和预测 ME 复发的有价值工具。
