Thompson W M, Halvorsen R A, Foster W L, Roberts L, Gibbons R
AJR Am J Roentgenol. 1986 Apr;146(4):703-10. doi: 10.2214/ajr.146.4.703.
This study reports a 4 year experience using CT for preoperative staging and for evaluation of patients with rectal and sigmoid carcinoma after surgery. All patients were evaluated on a GE 8800 scanner using 1 cm contiguous slices. Only 15 of the 25 preoperative patients were staged correctly. The other 10 patients were understaged by CT. The accuracy of detecting local invasion was 70%, but only seven (35%) of 20 patients had accurate assessment of lymph nodes. The overall accuracy of CT staging in the 46 postoperative patients was 87%, with a sensitivity of 91% and a specificity of 72%. Most recurrences were found in the pelvis; 16 patients had liver metastases, and metastatic disease obstructing the ureters was detected in eight patients. On the basis of these results, it was concluded that CT should not be used routinely to preoperatively stage patients with rectosigmoid carcinoma. However, all patients who have undergone resection for rectal or sigmoid carcinoma should have aggressive CT evaluation including a baseline study at 2-4 months and then follow-up studies at every 6 months for at least 2 years. All new or enlarging masses should have CT-guided biopsies. This approach may prolong survival by detecting early asymptomatic recurrences.
本研究报告了一项为期4年的经验,即使用CT进行术前分期以及评估直肠癌和乙状结肠癌患者术后情况。所有患者均在GE 8800扫描仪上进行检查,扫描层厚为1cm,层间距连续。25例术前患者中只有15例分期正确,另外10例患者被CT低估分期。检测局部侵犯的准确率为70%,但20例患者中只有7例(35%)对淋巴结的评估准确。46例术后患者CT分期的总体准确率为87%,敏感性为91%,特异性为72%。大多数复发发生在盆腔;16例患者有肝转移,8例患者检测到转移性疾病阻塞输尿管。基于这些结果,得出结论:CT不应常规用于直肠癌和乙状结肠癌患者的术前分期。然而,所有接受直肠癌或乙状结肠癌切除术的患者都应进行积极的CT评估,包括在术后2 - 4个月进行基线检查,然后每6个月进行一次随访检查,至少持续2年。所有新出现或增大的肿块都应进行CT引导下活检。这种方法可能通过检测早期无症状复发来延长生存期。