原子力显微镜分析早期毒性淀粉样 β 寡聚物的形态特性。
Analyzing Morphological Properties of Early-Stage Toxic Amyloid β Oligomers by Atomic Force Microscopy.
机构信息
Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland.
Department of Chemistry, University of Guelph, Guelph, ON, Canada.
出版信息
Methods Mol Biol. 2022;2402:227-241. doi: 10.1007/978-1-0716-1843-1_18.
PMID:34854048
Abstract
Protein misfolding diseases, like Alzheimer's, Parkinson's, and Huntington's disease, are associated with misfolded protein aggregation. Alzheimer's disease is related to a progressive neuronal death induced by small amyloid β oligomers. Here, we describe the procedure to prepare and identify different types of small toxic amyloid β oligomers by atomic force microscopy (AFM).
摘要
蛋白质错误折叠疾病，如阿尔茨海默病、帕金森病和亨廷顿病，与错误折叠的蛋白质聚集有关。阿尔茨海默病与小淀粉样β寡聚物诱导的进行性神经元死亡有关。在这里，我们描述了通过原子力显微镜（AFM）制备和鉴定不同类型的小毒性淀粉样β寡聚物的过程。
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