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5-氨基乙酰丙酸和柠檬酸亚铁改善果蝇肌肉衰老，延长健康寿命。

5-Aminolevulinic acid and sodium ferrous citrate ameliorate muscle aging and extend healthspan in Drosophila.

机构信息

Graduate School of Science, Tokyo Metropolitan University, Japan.

Division of Pharmaceutical Research, SBI Pharmaceuticals Co., Ltd., Tokyo, Japan.

出版信息

FEBS Open Bio. 2022 Jan;12(1):295-305. doi: 10.1002/2211-5463.13338. Epub 2021 Dec 12.

DOI:10.1002/2211-5463.13338
PMID:34854258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8727951/
Abstract

Declines in mitochondrial functions are associated with aging. The combination of 5-aminolevulinic acid (5-ALA) and sodium ferrous citrate (SFC) improves mitochondrial functions in cultured cells. In this study, we investigated the effects of dietary supplementation with 5-ALA and SFC (5-ALA/SFC) on the healthspan and life span of Drosophila melanogaster. Adult Drosophila fruit flies were fed cornmeal food containing various concentrations of 5-ALA/SFC. Locomotor functions, life span, muscle architecture, and age-associated changes in mitochondrial function were analyzed. We found that feeding 5-ALA/SFC mitigated age-associated declines in locomotor functions and extended organismal life span. Moreover, 5-ALA/SFC preserved muscle architecture and maintained the mitochondrial membrane potential in aged animals. Since 5-ALA phosphate/SFC is used as a human dietary supplement, our results suggest that it could be used to slow the age-related declines in muscle functions, prevent age-associated clinical conditions such as frailty, and extend healthspan and life span.

摘要

线粒体功能的下降与衰老有关。5-氨基酮戊酸（5-ALA）和柠檬酸亚铁钠（SFC）的联合使用可以改善培养细胞中的线粒体功能。在这项研究中，我们研究了膳食补充 5-ALA 和 SFC（5-ALA/SFC）对黑腹果蝇健康寿命和寿命的影响。成年果蝇被喂食含有不同浓度 5-ALA/SFC 的玉米粉食物。分析了运动功能、寿命、肌肉结构以及与年龄相关的线粒体功能变化。我们发现，喂食 5-ALA/SFC 可以减轻与年龄相关的运动功能下降，并延长生物体的寿命。此外，5-ALA/SFC 保持了肌肉结构，并维持了老年动物的线粒体膜电位。由于 5-ALA 磷酸盐/SFC 被用作人类膳食补充剂，我们的结果表明，它可以用于减缓与年龄相关的肌肉功能下降，预防与年龄相关的临床病症，如虚弱，并延长健康寿命和寿命。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0b5/8727951/67720523842c/FEB4-12-295-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0b5/8727951/79fdfe7af45b/FEB4-12-295-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0b5/8727951/545582f7e584/FEB4-12-295-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0b5/8727951/e78ff2cf6747/FEB4-12-295-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0b5/8727951/67720523842c/FEB4-12-295-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0b5/8727951/79fdfe7af45b/FEB4-12-295-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0b5/8727951/545582f7e584/FEB4-12-295-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0b5/8727951/e78ff2cf6747/FEB4-12-295-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0b5/8727951/67720523842c/FEB4-12-295-g005.jpg

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