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宫颈癌的外科治疗:共识与争议。

Surgery for cervical cancer: consensus & controversies.

机构信息

Division of Gynecologic Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.

出版信息

Indian J Med Res. 2021 Aug;154(2):284-292. doi: 10.4103/ijmr.IJMR_4240_20.

Abstract

Surgery plays an important role in the management of early-stage cervical cancer. Type III radical hysterectomy with bilateral pelvic lymph node dissection using open route is the standard surgical procedure. There is level I evidence against the use of laparoscopic/robotic approach for radical hysterectomy for cervical cancer. Emerging data support the use of sentinel lymph node biopsy and nerve sparing radical hysterectomy in carefully selected patients with early-stage disease. In locally advanced cervical cancer patients, the use of neoadjuvant chemotherapy (NACT) followed by radical surgery yields inferior disease-free survival compared to definitive concurrent chemoradiation therapy. Therefore, definitive concurrent chemoradiation is the standard treatment for locally advanced disease. Fertility preserving surgery is feasible in highly selected young patients. Role of less-radical surgical procedures in patients' with low-stage disease with good prognostic factors is under evaluation.

摘要

手术在早期宫颈癌的治疗中起着重要作用。采用开放式手术行 III 型根治性子宫切除术并双侧盆腔淋巴结清扫术是标准的手术程序。有一级证据反对将腹腔镜/机器人手术用于宫颈癌根治性子宫切除术。新出现的数据支持在精心挑选的早期疾病患者中使用前哨淋巴结活检和神经保留根治性子宫切除术。在局部晚期宫颈癌患者中,与根治性同步放化疗相比,新辅助化疗(NACT)后再行根治性手术的无疾病生存率较低。因此,根治性同步放化疗是局部晚期疾病的标准治疗方法。在高度选择的年轻患者中可行保留生育力的手术。对于低分期、预后良好的患者,较少激进的手术方式的作用正在评估中。

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