Department of Psychology, Adler University, Chicago, Illinois, USA.
Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Alzheimers Dement. 2022 Aug;18(8):1461-1471. doi: 10.1002/alz.12509. Epub 2021 Dec 2.
Although dementia prevalence differs by race, it remains unclear whether cognition and neuropsychiatric symptom severity differ between Black and White individuals with dementia.
Using National Alzheimer's Coordinating Center (NACC) data, we evaluated dementia prevalence in non-Hispanic Black and White participants and compared their clinicodemographic characteristics. We examined race differences in cognition, neuropsychiatric symptoms, and functional abilities in participants with dementia using multivariable linear and logistic regression models.
We included 5,700 Black and 31,225 White participants across 39 Alzheimer's Disease Research Centers. Of these, 1,528 (27%) Black and 11,267 (36%) White participants had dementia diagnoses. Despite having lower dementia prevalence, risk factors were more prevalent among Black participants. Black participants with dementia showed greater cognitive deficits, neuropsychiatric symptoms/severity, and functional dependence.
Despite lower dementia prevalence, Black participants with dementia had more dementia risk factors, as well as greater cognitive impairment and neuropsychiatric symptom severity than White participants.
尽管痴呆症的患病率因种族而异，但黑人和白人痴呆症患者的认知和神经精神症状严重程度是否存在差异仍不清楚。
我们使用国家阿尔茨海默病协调中心（NACC）的数据，评估了非西班牙裔黑人和白人参与者中的痴呆症患病率，并比较了他们的临床人口统计学特征。我们使用多变量线性和逻辑回归模型，检查了痴呆症参与者的认知、神经精神症状和功能能力方面的种族差异。
我们纳入了 39 个阿尔茨海默病研究中心的 5700 名黑人参与者和 31225 名白人参与者。其中，1528 名（27%）黑人参与者和 11267 名（36%）白人参与者被诊断为痴呆症。尽管痴呆症的患病率较低，但黑人参与者的风险因素更为普遍。患有痴呆症的黑人参与者表现出更大的认知缺陷、神经精神症状/严重程度和功能依赖。
尽管痴呆症的患病率较低，但患有痴呆症的黑人参与者比白人参与者有更多的痴呆症风险因素，以及更大的认知障碍和神经精神症状严重程度。
