tau 磷酸化位点丝氨酸 202 和丝氨酸 396 在慢性创伤性脑病和阿尔茨海默病中发生不同改变。
Tau phosphorylation sites serine202 and serine396 are differently altered in chronic traumatic encephalopathy and Alzheimer's disease.
机构信息
Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
VA Bedford Healthcare System, Bedford, Massachusetts, USA.
出版信息
Alzheimers Dement. 2022 Aug;18(8):1511-1522. doi: 10.1002/alz.12502. Epub 2021 Dec 2.
INTRODUCTION
Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impacts (RHI) typically sustained by contact sport athletes. Post-translation modifications to tau in CTE have not been well delineated or compared to Alzheimer's disease (AD).
METHODS
We measured phosphorylated tau epitopes within dorsolateral frontal cortex from post mortem brains with neither CTE nor AD (n = 108), CTE (n = 109), AD (n = 223), and both CTE and AD (n = 33).
RESULTS
Levels of hyperphosphorylated tau (p-tau) , p-tau , and p-tau were significantly increased in CTE. Total years of RHI exposure was significantly associated with increased p-tau levels (P = .001), but not p-tau . Instead, p-tau was most closely related to amyloid beta (Aβ) levels (P < .001). The p-tau :p-tau ratio was significantly increased in early and late CTE compared to AD.
DISCUSSION
In frontal cortex, p-tau is the most upregulated p-tau species in CTE, while p-tau is most increased in AD. p-tau and p-tau measurements may aid in developing biomarkers for disease.
简介
慢性创伤性脑病（CTE）是一种与反复头部撞击（RHI）相关的神经退行性tau 病，通常发生在接触性运动运动员身上。CTE 中 tau 的翻译后修饰尚未得到很好的描述，也未与阿尔茨海默病（AD）进行比较。
方法
我们测量了来自无 CTE 或 AD（n = 108）、CTE（n = 109）、AD（n = 223）和 CTE 和 AD 均有的死后大脑背外侧额叶皮质中磷酸化 tau 表位。
结果
CTE 中高度磷酸化 tau（p-tau）、p-tau 和 p-tau 的水平显著升高。RHI 暴露的总年限与 p-tau 水平的增加显著相关（P =.001），但与 p-tau 无关。相反，p-tau 与淀粉样蛋白 beta（Aβ）水平最密切相关（P <.001）。与 AD 相比，早期和晚期 CTE 中的 p-tau :p-tau 比值显著增加。
讨论
在前额叶皮质中，p-tau 是 CTE 中上调最明显的 p-tau 物种，而 p-tau 在 AD 中增加最多。p-tau 和 p-tau 的测量可能有助于开发疾病的生物标志物。
Zotero 插件