Sabet Kazuhiro, Panigrahi Arun, Chung Jo, Dayan Yoni
Department of Pediatrics, UC Davis Children's Hospital, Sacramento, California.
Division of Pediatric Hematology and Oncology, Department of Pediatrics, UC Davis Children's Hospital, Sacramento, California.
Pediatr Blood Cancer. 2022 Feb;69(2):e29450. doi: 10.1002/pbc.29450. Epub 2021 Dec 2.
We reviewed three very similar cases of acute-onset heart failure in children with acute myeloid leukemia who received anthracyclines during their treatment. All three children were diagnosed with recent Streptococcus viridans bacteremia and had persistent tachycardia prior to acute-onset heart failure with near-complete resolution within weeks. We hypothesize their heart failure was secondary to sepsis-induced cardiomyopathy with anthracycline-induced cardiac myocyte damage as a predisposing factor. We suggest prophylaxis and methods of early detection to prevent and better treat acute heart failure in pediatric oncology patients receiving anthracyclines.
我们回顾了3例急性髓系白血病患儿在治疗期间接受蒽环类药物治疗后出现急性心力衰竭的非常相似的病例。所有3名儿童均被诊断为近期感染草绿色链球菌菌血症，在急性心力衰竭发作前有持续性心动过速，数周内几乎完全缓解。我们推测他们的心力衰竭继发于脓毒症诱导的心肌病，蒽环类药物诱导的心肌细胞损伤为易感因素。我们提出了预防措施和早期检测方法，以预防和更好地治疗接受蒽环类药物治疗的儿科肿瘤患者的急性心力衰竭。
