Myeloma, Waldenstrom's & Amyloidosis Program, Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX 75390-8565, USA.
Future Oncol. 2022 Jan;18(3):277-289. doi: 10.2217/fon-2021-1090. Epub 2021 Dec 2.
Idecabtagene vicleucel (ide-cel), a novel chimeric antigen receptor (CAR) T-cell therapy targeting B-cell maturation antigen (BCMA), has recently gained approval by the US FDA for relapsed and refractory multiple myeloma (RRMM) after multicenter trials have demonstrated unprecedented results in this difficult-to-treat subgroup of patients. As the first CAR T-cell product approved for myeloma, ide-cel is poised to become a practice-changing treatment option. This first-in-class therapeutic offers hope for more durable remissions, as well as better quality of life, following a single infusion in a group of patients that previously had little hope. This paper reviews the ide-cel product in terms of design, pharmacology, efficacy and toxicity as described in studies reported to date.
伊达基奥仑赛(ide-cel),一种新型嵌合抗原受体(CAR)T 细胞疗法,针对 B 细胞成熟抗原(BCMA),最近获得美国 FDA 批准,用于复发和难治性多发性骨髓瘤(RRMM),此前多中心试验在这一治疗难度大的患者亚组中取得了前所未有的结果。作为首个获批用于骨髓瘤的 CAR T 细胞产品,ide-cel 有望成为一种改变治疗方式的选择。这种首创的治疗方法为一组此前希望渺茫的患者提供了更持久缓解和更高生活质量的希望。本文综述了 ide-cel 产品的设计、药理学、疗效和毒性,这些内容都是根据迄今为止报告的研究描述的。
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