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伊达基奥仑赛(ide-cel)嵌合抗原受体 T 细胞疗法治疗复发/难治性多发性骨髓瘤。

Idecabtagene vicleucel (ide-cel) CAR T-cell therapy for relapsed and refractory multiple myeloma.

机构信息

Myeloma, Waldenstrom's & Amyloidosis Program, Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX 75390-8565, USA.

出版信息

Future Oncol. 2022 Jan;18(3):277-289. doi: 10.2217/fon-2021-1090. Epub 2021 Dec 2.


DOI:10.2217/fon-2021-1090
PMID:34854741
Abstract

Idecabtagene vicleucel (ide-cel), a novel chimeric antigen receptor (CAR) T-cell therapy targeting B-cell maturation antigen (BCMA), has recently gained approval by the US FDA for relapsed and refractory multiple myeloma (RRMM) after multicenter trials have demonstrated unprecedented results in this difficult-to-treat subgroup of patients. As the first CAR T-cell product approved for myeloma, ide-cel is poised to become a practice-changing treatment option. This first-in-class therapeutic offers hope for more durable remissions, as well as better quality of life, following a single infusion in a group of patients that previously had little hope. This paper reviews the ide-cel product in terms of design, pharmacology, efficacy and toxicity as described in studies reported to date.

摘要

伊达基奥仑赛(ide-cel),一种新型嵌合抗原受体(CAR)T 细胞疗法,针对 B 细胞成熟抗原(BCMA),最近获得美国 FDA 批准,用于复发和难治性多发性骨髓瘤(RRMM),此前多中心试验在这一治疗难度大的患者亚组中取得了前所未有的结果。作为首个获批用于骨髓瘤的 CAR T 细胞产品,ide-cel 有望成为一种改变治疗方式的选择。这种首创的治疗方法为一组此前希望渺茫的患者提供了更持久缓解和更高生活质量的希望。本文综述了 ide-cel 产品的设计、药理学、疗效和毒性,这些内容都是根据迄今为止报告的研究描述的。

相似文献

[1]
Idecabtagene vicleucel (ide-cel) CAR T-cell therapy for relapsed and refractory multiple myeloma.

Future Oncol. 2022-1

[2]
Early Chimeric Antigen Receptor T Cell Expansion Is Associated with Prolonged Progression-Free Survival for Patients with Relapsed/Refractory Multiple Myeloma Treated with Ide-Cel: A Retrospective Monocentric Study.

Transplant Cell Ther. 2024-6

[3]
Real-life experiences with CAR T-cell therapy with idecabtagene vicleucel (ide-cel) for triple-class exposed relapsed/refractory multiple myeloma patients.

BMC Cancer. 2023-4-15

[4]
Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma.

N Engl J Med. 2021-2-25

[5]
Ide-cel or Standard Regimens in Relapsed and Refractory Multiple Myeloma.

N Engl J Med. 2023-3-16

[6]
Phase 2 results of idecabtagene vicleucel (ide-cel, bb2121) in Japanese patients with relapsed and refractory multiple myeloma.

Int J Hematol. 2023-5

[7]
Factors associated with refractoriness or early progression after idecabtagene vicleucel in patients with relapsed/ refractory multiple myeloma: US Myeloma Immunotherapy Consortium real world experience.

Haematologica. 2024-5-1

[8]
Recent Advances in the Use of Chimeric Antigen Receptor-Expressing T-Cell Therapies for Treatment of Multiple Myeloma.

Clin Lymphoma Myeloma Leuk. 2023-1

[9]
Chimeric Antigen Receptor T Cell Therapy for Myeloma: Where Are We Now and What Is Needed to Move Chimeric Antigen Receptor T Cells Forward to Earlier Lines of Therapy? Expert Panel Opinion from the American Society for Transplantation and Cellular Therapy.

Transplant Cell Ther. 2024-1

[10]
KarMMa-RW: comparison of idecabtagene vicleucel with real-world outcomes in relapsed and refractory multiple myeloma.

Blood Cancer J. 2021-6-18

引用本文的文献

[1]
Expanded and activated marrow-infiltrating lymphocytes exhibit potent antimyeloma activity against autologous multiple myeloma cells.

Transl Oncol. 2025-7-24

[2]
Current landscape of innovative drug development and regulatory support in China.

Signal Transduct Target Ther. 2025-7-22

[3]
Emerging Concepts in Immuno-Oncology: Insights from Natural Language Processing-Driven Co-Occurrence Analysis.

ACS Omega. 2025-6-27

[4]
Current Advances and Challenges in CAR-T Therapy for Hematological and Solid Tumors.

Immunotargets Ther. 2025-6-27

[5]
Ciltacabtagene Autoleucel for the Treatment of Relapsed/Refractory Multiple Myeloma: Efficacy, Safety, and Place in Therapy.

Cancer Manag Res. 2025-2-19

[6]
The Evolving Landscape in Multiple Myeloma: From Risk Stratification to T Cell-Directed Advanced Therapies.

Cancers (Basel). 2025-2-5

[7]
Cellular therapies in rheumatic and musculoskeletal diseases.

J Transl Autoimmun. 2024-12-16

[8]
The design of retroviral vectors used in the CAR-T products, risk management, and future perspective.

MedComm (2020). 2025-1-24

[9]
CAR-T cell therapy: developments, challenges and expanded applications from cancer to autoimmunity.

Front Immunol. 2025-1-9

[10]
Recommendations for the effective use of T-cell-redirecting therapies: a Canadian consensus statement.

Front Oncol. 2024-11-26

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