长链非编码 RNA 在急性髓系白血病中的多种功能：在病理生理学、预后和治疗耐药性中的新兴作用。
Diverse functions of long noncoding RNAs in acute myeloid leukemia: emerging roles in pathophysiology, prognosis, and treatment resistance.
机构信息
Cancer Science Institute, National University of Singapore, Singapore, Singapore.
Department of Pathology, Brigham & Women's Hospital.
出版信息
Curr Opin Hematol. 2022 Jan 1;29(1):34-43. doi: 10.1097/MOH.0000000000000692.
PURPOSE OF REVIEW
Advancements in the next-generation sequencing technologies have identified rare transcripts of long noncoding RNAs (lncRNAs) in the genome of cancers, including in acute myeloid leukemia (AML). The purpose of this review is to highlight the contribution of lncRNAs in AML pathogenesis, prognosis, and chemoresistance.
RECENT FINDINGS
Several studies have recently reported that deregulated lncRNAs are novel key players in the development of AML and are associated with AML pathophysiology and may serve as prognostic indicators. A few aberrantly expressed lncRNAs that correlated with the recurrent genetic mutations in AML such as NPM1 and RUNX1 have recently been characterized. Moreover, a few lncRNAs in MLL-rearranged leukemia have been described. Additionally, the involvement of lncRNAs in AML chemoresistance has been postulated.
SUMMARY
Investigating the functional roles of the noncoding regions including lncRNAs, may provide novel insights into the pathophysiology, refine the prognostic schema, and provide novel therapeutic treatment strategies in AML.
目的综述
下一代测序技术的进步已经在癌症（包括急性髓系白血病）的基因组中鉴定出长非编码 RNA（lncRNA）的稀有转录本。本文的目的是强调 lncRNA 在 AML 发病机制、预后和化疗耐药性中的作用。
最近的发现
最近有几项研究报道，失调的 lncRNA 是 AML 发展的新关键因素，与 AML 病理生理学相关，并可作为预后指标。最近已经对与 AML 中反复出现的遗传突变（如 NPM1 和 RUNX1）相关的一些异常表达的 lncRNA 进行了描述。此外，还描述了 MLL 重排白血病中的一些 lncRNA。此外，有人假设 lncRNA 参与了 AML 的化疗耐药性。
总结
研究非编码区域（包括 lncRNA）的功能作用，可能为 AML 的病理生理学提供新的见解，完善预后方案，并提供新的治疗策略。
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