Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, New South Wales, Australia.
School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia.
Wiley Interdiscip Rev RNA. 2023 Nov-Dec;14(6):e1796. doi: 10.1002/wrna.1796. Epub 2023 Jun 2.
Long noncoding RNAs (lncRNAs) are traditionally defined as RNA transcripts longer than 200 nucleotides that have no protein coding potential. LncRNAs have been identified to be dysregulated in various types of cancer, including the deadly hematopoietic cancer-acute myeloid leukemia (AML). Currently, survival rates for AML have reached a plateau necessitating new therapeutic targets and biomarkers to improve treatment options and survival from the disease. Therefore, the identification of lncRNAs as novel biomarkers and therapeutic targets for AML has major benefits. In this review, we assess the key studies which have recently identified lncRNAs as important molecules in AML and summarize the current knowledge of lncRNAs in AML. We delve into examples of the specific roles of lncRNA action in AML such as driving proliferation, differentiation block and therapy resistance as well as their function as tumor suppressors and utility as biomarkers. This article is categorized under: RNA in Disease and Development > RNA in Disease.
长链非编码 RNA（lncRNA）通常被定义为长度超过 200 个核苷酸且没有蛋白质编码潜力的 RNA 转录本。已经发现 lncRNA 在各种类型的癌症中失调，包括致命的血液系统癌症——急性髓系白血病（AML）。目前，AML 的生存率已经达到了一个平台期，需要新的治疗靶点和生物标志物来改善治疗方案并提高患者的生存率。因此，将 lncRNA 鉴定为 AML 的新型生物标志物和治疗靶点具有重要意义。在这篇综述中，我们评估了最近确定 lncRNA 为 AML 中重要分子的关键研究，并总结了 lncRNA 在 AML 中的现有知识。我们深入探讨了 lncRNA 在 AML 中的具体作用，例如驱动增殖、分化阻滞和治疗耐药性，以及它们作为肿瘤抑制因子的功能和作为生物标志物的用途。本文属于以下分类：RNA 在疾病与发育中的作用 > RNA 在疾病中的作用。
