He Jia, Ju JiYu, Wang XiaoDong
School of Clinical Medicine, Weifang Medical University, Weifang, China.
Department of Immunology, Weifang Medical University, Weifang, China.
Mol Biol Rep. 2022 Mar;49(3):2475-2485. doi: 10.1007/s11033-021-07034-0. Epub 2021 Dec 2.
Anti-citrullinated protein antibodies are a hallmark of rheumatoid arthritis. It is widely acknowledged that the presence of ACPAs is the result of the interaction of genes, the environment and epigenetic modifications. The mechanism by which the factors, especially citrullination and ACPA glycosylation, affect ACPAs is still unclear. In this article, we review the presence of the ACPAs in RA and their relationship with clinical manifestations. The pathogenicity of ACPAs and B cells in RA was also summarized. A growing body of evidence has shown that ACPA-positive patients have more serious bone erosion and destruction and poor clinical prognosis than ACPA-negative patients. Recently, with the direct study of citrullinated protein-reactive B cells, their role in the development of rheumatoid arthritis has been further understood. It indicates that further understanding of the mechanism of ACPAs and CP-reactive B cells would beneficial in the prevention and treatment of RA.
抗瓜氨酸化蛋白抗体是类风湿性关节炎的一个标志。人们普遍认为，抗瓜氨酸化蛋白抗体的存在是基因、环境和表观遗传修饰相互作用的结果。这些因素，尤其是瓜氨酸化和抗瓜氨酸化蛋白抗体糖基化，影响抗瓜氨酸化蛋白抗体的机制仍不清楚。在本文中，我们综述了类风湿性关节炎中抗瓜氨酸化蛋白抗体的存在情况及其与临床表现的关系。还总结了抗瓜氨酸化蛋白抗体和B细胞在类风湿性关节炎中的致病性。越来越多的证据表明，与抗瓜氨酸化蛋白抗体阴性的患者相比，抗瓜氨酸化蛋白抗体阳性的患者有更严重的骨质侵蚀和破坏，临床预后较差。最近，随着对瓜氨酸化蛋白反应性B细胞的直接研究，它们在类风湿性关节炎发展中的作用得到了进一步了解。这表明进一步了解抗瓜氨酸化蛋白抗体和瓜氨酸化蛋白反应性B细胞的机制将有助于类风湿性关节炎的预防和治疗。
