揭示 MYT1L 的奥秘：从重编程因子到神经元分化的多面调控因子。
Unraveling the mysteries of MYT1L: From reprogramming factor to multifaceted regulator of neuronal differentiation.
机构信息
Child Health Institute of New Jersey and Department of Neuroscience and Cell Biology, Rutgers - Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
Child Health Institute of New Jersey and Department of Neuroscience and Cell Biology, Rutgers - Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
出版信息
Neuron. 2021 Dec 1;109(23):3713-3715. doi: 10.1016/j.neuron.2021.11.006.
In this issue of Neuron, Chen et al. (2021) generated a mouse model for haploinsufficiency of MYT1L. MYT1L is widely used in neuronal reprogramming, and de novo mutations have been linked to a neurodevelopmental syndrome. Extensive characterization in this study better delineates MYT1L's role in transcriptional regulation and neuronal differentiation.
在本期《神经元》杂志中，Chen 等人（2021 年）构建了 MYT1L 杂合缺失的小鼠模型。MYT1L 广泛应用于神经元重编程，而从头突变与神经发育综合征有关。本研究中的广泛特征描述更好地描绘了 MYT1L 在转录调控和神经元分化中的作用。
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