Instituto de Investigaciones en Ciencias Químicas, Facultad de Ciencias Químicas y Tecnológicas, Universidad Católica de Cuyo, Sede San Juan, Argentina.
Department of Structural and Functional Biology, UNESP-São Paulo State University, Institute of Biosciences, Botucatu 18618-689, São Paulo, Brazil.
Life Sci. 2022 Jan 1;288:120191. doi: 10.1016/j.lfs.2021.120191. Epub 2021 Nov 29.
Vascular inflammation is one of the main activating stimuli of cardiovascular disease and its uncontrolled development may worsen the progression and prognosis of these pathologies. Therefore, the search for new therapeutic options to treat this condition is undoubtedly needed. In this regard, it may be better to repurpose endogenous anti-inflammatory compounds already known, in addition to synthesizing new compounds for therapeutic purposes. It is well known that vitamin D, anandamide, and melatonin are promising endogenous substances with powerful and wide-spread anti-inflammatory properties. Currently, the epigenetic mechanisms underlying these effects are often unknown. This review summarizes the potential epigenetic mechanisms by which vitamin D, anandamide, and melatonin attenuate vascular inflammation. This information could contribute to the improvement in the therapeutic management of multiple pathologies associated with blood vessel inflammation, through the pharmacological manipulation of new target sites that until now have not been addressed.
血管炎症是心血管疾病的主要激活刺激因素之一，其不受控制的发展可能会使这些病理的进展和预后恶化。因此，毫无疑问需要寻找新的治疗方法来治疗这种情况。在这方面，重新利用已经已知的内源性抗炎化合物，以及合成用于治疗目的的新化合物可能会更好。众所周知，维生素 D、内源性大麻素和褪黑素是具有强大且广泛抗炎特性的有前途的内源性物质。目前，这些作用的表观遗传机制尚不清楚。本综述总结了维生素 D、内源性大麻素和褪黑素减轻血管炎症的潜在表观遗传机制。这些信息可能有助于通过对迄今为止尚未涉及的新靶位进行药物干预来改善与血管炎症相关的多种病理的治疗管理。
