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从一名慢性囊性纤维化患者中分离出的土居菌。墨西哥的首例报告以及铜绿假单胞菌共感染促进细胞外中性粒细胞诱捕网加速形成且数量增加的证据。

Inquilinus limosus isolated from a patient with chronic cystic fibrosis. First report in Mexico and evidence that co-infection with Pseudomonas aeruginosa promotes the accelerated and increased formation of extracellular neutrophil traps.

作者信息

Ríos-López A L, Bustamante A E, González G M, Llaca-Diaz J M, Sánchez-González A

机构信息

Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, 64460, Nuevo León, Mexico.

Hospital Universitario, CEPREP, Edificio Rodrigo Barragán, Universidad Autónoma de Nuevo León, Monterrey, 64460, Nuevo León, Mexico.

出版信息

Indian J Med Microbiol. 2022 Jan-Mar;40(1):156-159. doi: 10.1016/j.ijmmb.2021.11.010. Epub 2021 Dec 2.

Abstract

Cystic fibrosis is characterized by abnormal mucous secretions in the lungs that favor the proliferation of colonizing bacteria, with Pseudomonas aeruginosa and Staphylococcus aureus being the most isolated, however, other less known species could also have an impact on the health of the patient. Here we demonstrate the isolation and antibiotic resistance profiles of Inquilinus limosus, a rarely reported multidrug resistant bacterium, and compare them to a co-infectant strain of Pseudomonas aeruginosa. Likewise, we found that co-infection with both bacteria promotes increased formation of neutrophil extracellular traps, which can have an impact on the disease severity and make treatment difficult.

摘要

囊性纤维化的特征是肺部黏液分泌异常,有利于定殖细菌的增殖,其中铜绿假单胞菌和金黄色葡萄球菌最为常见,然而,其他不太知名的菌种也可能对患者健康产生影响。在这里,我们展示了一种罕见报道的多重耐药菌——栖居菌的分离及抗生素耐药谱,并将其与铜绿假单胞菌的共感染菌株进行比较。同样,我们发现这两种细菌的共感染会促进中性粒细胞胞外陷阱的形成增加,这可能会影响疾病的严重程度并使治疗变得困难。

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