时间采样、葡萄糖代谢率及血脑屏障破坏对含和不含血管腔室的FDG模型的影响：PET在人脑肿瘤中的研究

Effects of temporal sampling, glucose metabolic rates, and disruptions of the blood-brain barrier on the FDG model with and without a vascular compartment: studies in human brain tumors with PET.

作者信息

Hawkins R A, Phelps M E, Huang S C

出版信息

J Cereb Blood Flow Metab. 1986 Apr;6(2):170-83. doi: 10.1038/jcbfm.1986.30.

DOI:10.1038/jcbfm.1986.30

Abstract

The addition of a cerebral blood volume (CBV) compartment in the [18F]2-fluoro-2-deoxy-D-glucose (FDG) model produces estimates of local CBV simultaneously with glucose metabolic rates when kinetic FDG studies are performed. We investigated the influence of this term upon CMRglc values in a series of brain tumor patients and found that significant overestimations of CMRglc are possible if the effect of CBV upon the model is ignored. The magnitude of this potential overestimation is directly related to the absolute value of CBV locally and inversely related to the CMRglc value. The kinetic estimates also permitted an evaluation of the FDG model in an environment with a variable disruption of the blood-brain barrier. Incorporating the vascular compartment in the FDG model also frequently improved the statistical accuracy of model fits to tissue kinetic data. The sampling requirements for this model configuration were also investigated in a series of computer simulations.

摘要

在[18F]2-氟-2-脱氧-D-葡萄糖（FDG）模型中加入脑血容量（CBV）隔室后，在进行FDG动力学研究时，可同时得出局部CBV估计值和葡萄糖代谢率。我们在一系列脑肿瘤患者中研究了该参数对葡萄糖代谢率（CMRglc）值的影响，发现如果忽略CBV对模型的影响，CMRglc可能会被显著高估。这种潜在高估的程度与局部CBV的绝对值直接相关，与CMRglc值呈负相关。动力学估计还允许在血脑屏障存在可变破坏的环境中评估FDG模型。在FDG模型中纳入血管隔室也经常提高模型对组织动力学数据拟合的统计准确性。还通过一系列计算机模拟研究了这种模型配置的采样要求。