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Impaired Humoral Response to Third Dose of BNT162b2 mRNA COVID-19 Vaccine Despite Detectable Spike Protein-specific T cells in Lung Transplant Recipients.尽管肺移植受者体内可检测到刺突蛋白特异性T细胞，但对第三剂BNT162b2 mRNA新冠疫苗的体液免疫反应受损。
Transplantation. 2022 Mar 1;106(3):e183-e184. doi: 10.1097/TP.0000000000004021.
2
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Comparison of SARS-CoV-2 Antibody Response 4 Weeks After Homologous vs Heterologous Third Vaccine Dose in Kidney Transplant Recipients: A Randomized Clinical Trial.肾移植受者同源与异源第三剂疫苗接种后 4 周时的 SARS-CoV-2 抗体反应比较：一项随机临床试验。
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Humoral Response after SARS-CoV-2 mRNA Vaccination in a Cohort of Hemodialysis Patients and Kidney Transplant Recipients.血液透析患者和肾移植受者队列中 SARS-CoV-2 mRNA 疫苗接种后的体液反应。
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Humoral response to heterologous prime-booster vaccination in heart transplant recipients aged 18-70 years primed with a viral vector SARS-CoV-2 vaccine.18-70 岁心脏移植受者使用病毒载体 SARS-CoV-2 疫苗进行异源初免-加强免疫后的体液免疫反应。
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The third dose of mRNA SARS-CoV-2 vaccines enhances the spike-specific antibody and memory B cell response in myelofibrosis patients.mRNA SARS-CoV-2 疫苗的第三剂加强了骨髓纤维化患者的刺突特异性抗体和记忆 B 细胞反应。
Front Immunol. 2022 Sep 29;13:1017863. doi: 10.3389/fimmu.2022.1017863. eCollection 2022.

引用本文的文献

1
High Rate of Antibody Response to Multiple Doses of the COVID-19 Vaccine in Liver Transplant Recipients: Analysis of Predictive Factors.肝移植受者对多剂新冠疫苗的高抗体反应率：预测因素分析
Vaccines (Basel). 2025 Mar 26;13(4):352. doi: 10.3390/vaccines13040352.
2
Predominantly defective CD8 T cell immunity to SARS-CoV-2 mRNA vaccination in lung transplant recipients.肺移植受者对 SARS-CoV-2 mRNA 疫苗接种的主要缺陷性 CD8 T 细胞免疫。
J Transl Med. 2023 Jun 8;21(1):374. doi: 10.1186/s12967-023-04234-z.
3
Immunogenicity, Safety, and Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infections After Coronavirus Disease 2019 Vaccination in Organ Transplant Recipients: A Prospective Multicenter Canadian Study.器官移植受者接种2019冠状病毒病疫苗后的免疫原性、安全性及严重急性呼吸综合征冠状病毒2突破性感染：一项加拿大前瞻性多中心研究
Open Forum Infect Dis. 2023 Apr 13;10(5):ofad200. doi: 10.1093/ofid/ofad200. eCollection 2023 May.
4
Immunogenicity of a Third Dose of BNT162b2 Vaccine among Lung Transplant Recipients-A Prospective Cohort Study.肺移植受者中第三剂BNT162b2疫苗的免疫原性——一项前瞻性队列研究
Vaccines (Basel). 2023 Apr 4;11(4):799. doi: 10.3390/vaccines11040799.
5
A new set-up of vanishing antibodies: A biennial follow-up of five different clients' humoral responses against SARS-CoV-2 after systemic vaccination in an oncology hospital in Poland.消失抗体的新情况：波兰一家肿瘤医院对五名不同患者在全身接种新冠疫苗后针对SARS-CoV-2的体液反应进行的两年随访。
Health Sci Rep. 2023 Mar 30;6(4):e1172. doi: 10.1002/hsr2.1172. eCollection 2023 Apr.
6
Efficacy of pre-exposure prophylaxis to prevent SARS-CoV-2 infection after lung transplantation: a two center cohort study during the omicron era.奥密克戎时代肺移植后预防 SARS-CoV-2 感染的暴露前预防效果：一项两中心队列研究。
Infection. 2023 Oct;51(5):1481-1489. doi: 10.1007/s15010-023-02018-7. Epub 2023 Mar 16.
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Humoral and cellular immune response after severe acute respiratory syndrome coronavirus 2 messenger ribonucleic acid vaccination in heart transplant recipients: An observational study in France.严重急性呼吸综合征冠状病毒2信使核糖核酸疫苗接种后心脏移植受者的体液和细胞免疫反应：法国的一项观察性研究
Front Med (Lausanne). 2022 Oct 26;9:1027708. doi: 10.3389/fmed.2022.1027708. eCollection 2022.
8
Efficacy and safety of the SARS-CoV-2 mRNA vaccine in lung transplant recipients: a possible trigger of rejection.新型冠状病毒疫苗在肺移植受者中的疗效和安全性：排斥反应的一个潜在触发因素。
Gen Thorac Cardiovasc Surg. 2023 Apr;71(4):251-257. doi: 10.1007/s11748-022-01887-3. Epub 2022 Oct 26.
9
Immunogenicity and safety of the booster BNT162b2 vaccine in patients with axial spondyloarthritis treated with biological disease-modifying drugs.生物制剂治疗的中轴型脊柱关节炎患者接种 BNT162b2 疫苗加强针的免疫原性和安全性。
Front Immunol. 2022 Sep 23;13:1010808. doi: 10.3389/fimmu.2022.1010808. eCollection 2022.
10
Outcome of lung transplant recipients infected with SARS-CoV-2/Omicron/B.1.1.529: a Nationwide German study.SARS-CoV-2/Omicron/B.1.1.529 感染肺移植受者的结局：一项全国性的德国研究。
Infection. 2023 Jun;51(3):749-757. doi: 10.1007/s15010-022-01914-8. Epub 2022 Sep 9.

Impaired Humoral Response to Third Dose of BNT162b2 mRNA COVID-19 Vaccine Despite Detectable Spike Protein-specific T cells in Lung Transplant Recipients.

作者信息

Havlin Jan, Skotnicova Aneta, Dvorackova Eliska, Hubacek Petr, Svorcova Monika, Lastovicka Jan, Sediva Anna, Kalina Tomas, Lischke Robert

机构信息

Prague Lung Transplant Program, 3rd Department of Surgery, Charles University in Prague and Motol University Hospital, Prague, Czech Republic.

CLIP - Childhood Leukaemia Investigation Prague, Department of Pediatric Hematology and Oncology, Charles University in Prague and Motol University Hospital, Prague, Czech Republic.

出版信息

Transplantation. 2022 Mar 1;106(3):e183-e184. doi: 10.1097/TP.0000000000004021.

DOI:10.1097/TP.0000000000004021
PMID:34856599
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8862668/
Abstract
摘要