Department of Obstetrics and Gynecology, Ohta Nisinouchi Hospital, Fukushima, Japan.
Department of Obstetrics and Gynecology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
J Obstet Gynaecol Res. 2022 Feb;48(2):379-384. doi: 10.1111/jog.15113. Epub 2021 Dec 2.
The effect of placenta previa on age-specific placental size has not yet been elucidated. This study aimed to examine the effect of placenta previa on the Japanese standardized z-scores of placental size.
This retrospective cohort study included Japanese participants from Ohta Nishinouchi Hospital with single pregnancies who gave birth during 2013-2019. The participants were categorized into two groups based on the presence or absence of placenta previa. Multiple linear regression analyses were used to identify the association of placenta previa with the z-score of placental size, after adjusting for factors, such as maternal smoking status, maternal age, assisted reproductive technology, myoma uteri, uterine anomaly, maternal hypertension at the time of pregnancy, and body mass index before pregnancy.
A total of 4071 Japanese women (76 with placenta previa and 3995 without placenta previa) were identified. Placenta previa significantly increased the placental weight z-score (partial regression coefficient: 0.44, 95% confidence interval 0.10-0.70, p < 0.001).
Placenta previa increased the age-specific placental size. Further studies are required to examine whether placenta previa is associated with the risk of obstetrics complications related to the placental size.
胎盘前置对胎盘大小的年龄特异性影响尚未阐明。本研究旨在探讨胎盘前置对日本标准化胎盘大小 z 评分的影响。
这是一项回顾性队列研究，纳入了 2013 年至 2019 年期间在大戸西野医院分娩的单胎妊娠日本参与者。根据是否存在胎盘前置，将参与者分为两组。调整了母亲吸烟状况、母亲年龄、辅助生殖技术、子宫肌瘤、子宫畸形、妊娠时的高血压和妊娠前的体重指数等因素后，采用多元线性回归分析来确定胎盘前置与胎盘大小 z 评分之间的关联。
共确定了 4071 名日本妇女（76 名有胎盘前置，3995 名无胎盘前置）。胎盘前置显著增加了胎盘重量 z 评分（偏回归系数：0.44，95%置信区间 0.10-0.70，p<0.001）。
胎盘前置增加了胎盘的年龄特异性大小。需要进一步研究以探讨胎盘前置是否与与胎盘大小相关的产科并发症风险有关。
