Baldwin R L, Formby C
Laryngoscope. 1986 Apr;96(4):420-9. doi: 10.1288/00005537-198604000-00015.
Systemic blood flow, blood flow to the peripheral skin, middle ear, and temporal bone, and that to the inner ear of normal volunteers was manipulated selectively through the use of vasodilator drugs. The effect of selective vasodilation was monitored via changes in the temporal course of the slow-phase velocity of nystagmus evoked by bithermal caloric irrigation. Drug influenced eye velocities were compared with control values measured before drug administration. Eye velocities measured after niacin (a peripheral vasodilator) administration generally were greater than control values, whereas eye velocities measured after papaverine (a central vasodilator) and histamine (a systemic vasodilator) administration typically were less than control values. These findings, with the exception of the cool caloric/niacin condition, are consistent with a model of vestibular dynamics and measurements of cochlear blood flow in animal models.
通过使用血管扩张药物，对正常志愿者的全身血流量、流向外周皮肤、中耳和颞骨以及内耳的血流量进行了选择性调控。通过监测冷热交替灌流诱发的眼球震颤慢相速度的时间进程变化，来观察选择性血管扩张的效果。将药物影响后的眼球速度与给药前测得的对照值进行比较。服用烟酸（一种外周血管扩张剂）后测得的眼球速度通常高于对照值，而服用罂粟碱（一种中枢血管扩张剂）和组胺（一种全身血管扩张剂）后测得的眼球速度通常低于对照值。除了冷灌流/烟酸的情况外，这些发现与动物模型中的前庭动力学模型和耳蜗血流量测量结果一致。
